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  Peripheral serotonin 1B receptor transcription predicts the effect of acute tryptophan depletion on risky decision-making

Faulkner, P., Mancinelli, F., Lockwood, P., Matarin, M., Dolan, R., Wood, N., et al. (2017). Peripheral serotonin 1B receptor transcription predicts the effect of acute tryptophan depletion on risky decision-making. International Journal of Neuropsychopharmacology, 20(1), 58-66. doi:10.1093/ijnp/pyw075.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-C31A-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-C31B-4
Genre: Journal Article

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 Creators:
Faulkner, P, Author
Mancinelli, F, Author
Lockwood, PL, Author
Matarin, M, Author
Dolan, RJ, Author
Wood, NW, Author
Dayan, P1, Author              
Roiser, JP, Author
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1External Organizations, ou_persistent22              

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 Abstract: Background The effects of acute tryptophan depletion on human decision-making suggest that serotonin modulates the processing of rewards and punishments. However, few studies have assessed which of the many types of serotonin receptors are responsible. Methods Using a within-subject, double-blind, sham-controlled design in 26 subjects, we examined whether individual differences in serotonin system gene transcription, measured in peripheral blood, predicted the effect of acute tryptophan depletion on decision-making. Participants performed a task in which they chose between successive pairs of fixed, lower-stakes (control) and variable, higher-stakes (experimental) gambles, each involving wins or losses. In 21 participants, mRNA from 9 serotonin system genes was measured in whole blood prior to acute tryptophan depletion: 5-HT1B, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT3A, 5-HT3E, 5-HT7 (serotonin receptors), 5-HTT (the serotonin transporter), and tryptophan hydroxylase 1. Results Acute tryptophan depletion did not significantly influence participants’ sensitivity to probability, wins, or losses, although there was a trend for a lower tendency to choose experimental gambles overall following depletion. Significant positive correlations, which survived correction for multiple comparisons, were detected between baseline 5-HT1B mRNA levels and acute tryptophan depletion-induced increases in both the overall tendency to choose the experimental gamble and sensitivity to wins. No significant relationship was observed with any other peripheral serotonin system markers. Computational analyses of decision-making data provided results consistent with these findings. Conclusions These results suggest that the 5-HT1B receptor may modulate the effects of acute tryptophan depletion on risky decision-making. Peripheral levels of serotonin markers may predict response to treatments that act upon the serotonin system, such as selective serotonin reuptake inhibitors.

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Language(s): eng - English
 Dates: 2016-092017-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/ijnp/pyw075
 Degree: -

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Title: International Journal of Neuropsychopharmacology
  Other : Int. J. Neuropsychopharmacol.
Source Genre: Journal
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Publ. Info: Cambridge : Cambridge University Press
Pages: - Volume / Issue: 20 (1) Sequence Number: - Start / End Page: 58 - 66 Identifier: ISSN: 1461-1457
CoNE: https://pure.mpg.de/cone/journals/resource/963017835281