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  Dopamine restores reward prediction errors in old age

Chowdhury, R., Guitart-Masip, M., Lambert, C., Dayan, P., Huys, Q., Düzel, E., et al. (2013). Dopamine restores reward prediction errors in old age. Nature Neuroscience, 16(5), 648-653. doi:10.1038/nn.3364.

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https://www.nature.com/articles/nn.3364.pdf (Verlagsversion)
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 Urheber:
Chowdhury, R, Autor
Guitart-Masip, M, Autor
Lambert, C, Autor
Dayan, P1, Autor           
Huys, Q1, Autor
Düzel, E1, Autor
Dolan, RJ, Autor
Affiliations:
1External Organizations, ou_persistent22              

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 Zusammenfassung: Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value, resulting in an incomplete reward prediction error (RPE) signal in the nucleus accumbens, a brain region that receives rich input projections from substantia nigra/ventral tegmental area (SN/VTA) dopaminergic neurons. Structural connectivity between SN/VTA and striatum, measured by diffusion tensor imaging, was tightly coupled to inter-individual differences in the expression of this expected reward value signal. The dopamine precursor levodopa (L-DOPA) increased the task-based learning rate and task performance in some older adults to the level of young adults. This drug effect was linked to restoration of a canonical neural RPE. Our results identify a neurochemical signature underlying abnormal reward processing in older adults and indicate that this can be modulated by L-DOPA.

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Sprache(n): eng - English
 Datum: 2013-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/nn.3364
 Art des Abschluß: -

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Titel: Nature Neuroscience
  Andere : Nat. Neurosci.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York, NY : Nature America Inc.
Seiten: - Band / Heft: 16 (5) Artikelnummer: - Start- / Endseite: 648 - 653 Identifikator: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931