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  The impulsive brain: Neural underpinnings of binge eating behavior in normal-weight adults

Oliva, R., Morys, F., Horstmann, A., Castiello, U., & Begliomini, C. (2019). The impulsive brain: Neural underpinnings of binge eating behavior in normal-weight adults. Appetite, 136, 33-49. doi:10.1016/j.appet.2018.12.043.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-C6CF-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-DABD-4
Genre: Journal Article

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 Creators:
Oliva, Rossella 1, Author
Morys, Filip2, 3, Author              
Horstmann, Annette2, 3, Author              
Castiello, Umberto1, Author
Begliomini, Chiara1, Author
Affiliations:
1Department of General Psychology, University of Padova, Italy, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Impulsivity; Binge eating; Functional magnetic resonance imaging; Go/no-go; Stop signal task; Middle frontal gyrus
 Abstract: Converging evidence suggests that dysfunctional inhibitory control might be at the roots of overeating and binge eating disorder (BED). The majority of these results stems from studies on obese populations, however we hypothesized that potential prodromes might be evident also in non-clinical conditions, when binge eating episodes are present (without a diagnosis of BED) and a normal Body Mass Index is preserved. To explore this issue, brain activity of 42 normal weight individuals with and without binge eating episodes (21 binge eaters and 21 non-binge eaters, BE and non-BE respectively) was assessed by means of functional magnetic resonance imaging (fMRI) during response inhibition tasks. We adopted a food-modified version of a go/no-go (GNG) and stop signal task (SST): these tasks investigate different aspects of inhibitory control (action restraint and cancellation) that have been rarely studied in the same individuals but that are known to involve different neural networks. In addition, impulsivity traits were assessed with self-report instruments. Despite similar behavioral performances, the two groups differed in trait impulsivity and brain activity. The fMRI results revealed differential engagement of fronto-striatal regions between the groups during the tasks. The BE group, compared to non-BE, showed lower activation of the right middle frontal gyrus (MFG) and Putamen during the GNG task, and higher activation of the left MFG during the SST. These findings provide evidence of a dissociation of the neural underpinnings of action restraint and cancellation in impulsive individuals. Moreover, they add support to the hypothesis that impulsivity may be a possible hallmark of binge eating behavior (in the absence of weight or full-blown eating disorders) and yield new insights on the role of regions typically involved in response inhibition and selection as possible substrates of impulsive eating.

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Language(s): eng - English
 Dates: 2018-12-172018-07-182018-12-292019-01-042019-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.appet.2018.12.043
PMID: 30615922
Other: Epub ahead of print
PII: S0195-6663(18)31039-0
 Degree: -

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Funding organization : Italian Ministry of University and Research (MIUR)

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Title: Appetite
Source Genre: Journal
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Publ. Info: London : Academic Press
Pages: - Volume / Issue: 136 Sequence Number: - Start / End Page: 33 - 49 Identifier: ISSN: 0195-6663
CoNE: https://pure.mpg.de/cone/journals/resource/954922648093