English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Changes in Cortical Activation during Retrieval of Clock Time Representations in Patients with Mild Cognitive Impairment and Early Alzheimer’s Disease

Leyhe, T., Erb, M., Milian, M., Eschweiler, G., Ethofer, T., Grodd, W., et al. (2009). Changes in Cortical Activation during Retrieval of Clock Time Representations in Patients with Mild Cognitive Impairment and Early Alzheimer’s Disease. Dementia and Geriatric Cognitive Disorders, 27(2), 117-132. doi:10.1159/000197930.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0002-C98E-C Version Permalink: http://hdl.handle.net/21.11116/0000-0006-02C7-7
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
https://www.karger.com/Article/Abstract/197930 (Publisher version)
Description:
-

Creators

show
hide
 Creators:
Leyhe, T, Author
Erb, M1, Author              
Milian, M, Author
Eschweiler, GW, Author              
Ethofer, T, Author
Grodd, W1, Author              
Saur, R, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Objective: We investigated healthy controls (HCs), and patients with mild cognitive impairment (MCI) and early Alzheimer’s disease (AD) to identify neuronal correlates of clock time representation and changes resulting from neurodegenerative processes using functional magnetic resonance imaging. Methods: Two clock-specific tasks demanding conceptual knowledge of clock hands, i.e. a minute hand and an hour hand task, were compared with a semantic control task. Results: We observed that the minute hand task provoked a stronger activation of areas in the parietal lobes known to be involved in spatial mental imagery, while the semantic task primarily activated regions of the superior temporal lobes associated with verbal conceptual knowledge. The performance of the MCI group did not differ from that of the HC group, but additional activation was found in several brain regions. Decreased activation was detected during the minute hand task in the right middle temporal gyrus. Patients with early AD showed deteriorated performance in both clock tasks along with reduced activation in the occipital lobes and the left fusiform gyrus. Additional activation was detected in the precuneus. Conclusions: The fusiform gyrus might be crucial for the visual-semantic retrieval of clock time representation. In patients with early AD, access to this visual-semantic knowledge appears to be reduced.

Details

show
hide
Language(s):
 Dates: 2009-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1159/000197930
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Dementia and Geriatric Cognitive Disorders
  Other : Dement. Geriatr. Cogn. Disord.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Basel : Karger
Pages: - Volume / Issue: 27 (2) Sequence Number: - Start / End Page: 117 - 132 Identifier: ISSN: 1420-8008
CoNE: https://pure.mpg.de/cone/journals/resource/954926994173