English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Sensory Experience Alters Specific Branches of Individual Corticocortical Axons during Development

Bruno, R., Hahn, T., Wallace, D., de Kock, C., & Sakmann, B. (2009). Sensory Experience Alters Specific Branches of Individual Corticocortical Axons during Development. The Journal of Neuroscience, 29(10), 3172-3181. doi:10.1523/JNEUROSCI.5911-08.2009.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Bruno, RM, Author
Hahn, TTG, Author
Wallace, DJ1, 2, 3, Author              
de Kock , CPJ, Author
Sakmann, B, Author
Affiliations:
1Former Research Group Network Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528697              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Research Group Neural Population Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497807              

Content

show
hide
Free keywords: -
 Abstract: Sensory experience can, over the course of days to weeks, produce long-lasting changes in brain function. Recent studies suggest that functional plasticity is mediated by alterations of the strengths of existing synapses or dynamics of dendritic spines. Alterations of cortical axons could also contribute to functional changes, but little is known about the effects of experience at the level of individual corticocortical axons. We reconstructed individual layer (L) 2/3 pyramidal neurons filled in vivo in developing barrel cortex of control and partially sensory-deprived rats. L2 axons had larger field spans than L3 axons but were otherwise equivalently affected by deprivation. Whisker trimming over similar to 2 weeks markedly reduced overall length of axonal branches in L2/3, but individual horizontal axons were as likely to innervate deprived areas as spared ones. The largest effect of deprivation was instead to reduce the length of those axonal branches in L2/3 oriented toward deprived regions. Thus, the location of a branch relative to its originating soma, rather than its own location within any specific cortical column, was the strongest determinant of axonal organization. Individual axons from L2/3 into L5/6 were similarly altered by whisker trimming although to a lesser extent. Thus, sensory experience over relatively short timescales may change the patterning of specific axonal branches within as well as between cortical columns during development.

Details

show
hide
Language(s): eng - English
 Dates: 2009-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 429909
DOI: 10.1523/JNEUROSCI.5911-08.2009
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 29 (10) Sequence Number: - Start / End Page: 3172 - 3181 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187