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  Unforgettable force - crosstalk and memory of mechanosensitive structures.

Kanoldt, V., Fischer, L., & Grashoff, C. (2018). Unforgettable force - crosstalk and memory of mechanosensitive structures. Biological Chemistry, 687-698. doi:10.1515/hsz-2018-0328.

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Genre: Journal Article

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 Creators:
Kanoldt, Verena1, Author              
Fischer, Lisa1, Author              
Grashoff, Carsten1, Author              
Affiliations:
1Grashoff, Carsten / Molecular Mechanotransduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565150              

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Free keywords: biophysics; cell biology; mechanical memory; mechanotransduction
 Abstract: The ability of cells to sense and respond to mechanical stimuli is crucial for many developmental and homeostatic processes, while mechanical dysfunction of cells has been associated with numerous pathologies including muscular dystrophies, cardiovascular defects, and epithelial disorders. Yet, how cells detect and process mechanical information is still unclear. In this review, we outline major mechanisms underlying cellular mechanotransduction and we summarize the current understanding of how cells integrate information from distinct mechanosensitive structures to mediate complex mechanoresponses. We also discuss the concept of mechanical memory and describe how cells store information on previous mechanical events for different periods of time.

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Language(s): eng - English
 Dates: 2018-12-202018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 30465711
DOI: 10.1515/hsz-2018-0328
 Degree: -

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Project name : 10.13039/501100001659 (GR 3399/6–1)
Grant ID : 3399/6–1
Funding program : DFG-ANR program
Funding organization : German Research Council
Project name : Collaborative Research Centre SFB863 (B9) and the Human Frontier Science Program (RGP0024)
Grant ID : -
Funding program : -
Funding organization : -

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Title: Biological Chemistry
  Other : Biological Chemistry Hoppe-Seyler (Berlin)
  Abbreviation : Biol Chem Hoppe Seyler
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin : W. de Gruyter
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 687 - 698 Identifier: ISSN: 1437-4315
ISSN: 1431-6730
CoNE: https://pure.mpg.de/cone/journals/resource/954927622123