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  Genome Analysis of the Meat Starter Culture Bacterium Staphylococcus carnosus TM300

Rosenstein, R., Nerz, C., Biswas, L., Resch, A., Raddatz, G., Schuster, S., et al. (2009). Genome Analysis of the Meat Starter Culture Bacterium Staphylococcus carnosus TM300. Applied and Environmental Microbiology, 75(3), 811-822. doi:10.1128/AEM.01982-08.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-CA2F-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-CA30-4
Genre: Journal Article

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Rosenstein, R, Author
Nerz, C, Author
Biswas, L, Author
Resch, A, Author
Raddatz, G1, 2, Author              
Schuster, SC, Author              
Götz, F, Author
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The Staphylococcus carnosus genome has the highest GC content of all sequenced staphylococcal genomes, with 34.6%, and therefore represents a species that is set apart from S. aureus, S. epidermidis, S. saprophyticus, and S. haemolyticus. With only 2.56 Mbp, the genome belongs to a family of smaller staphylococcal genomes, and the ori and ter regions are asymmetrically arranged with the replichores I (1.05 Mbp) and II (1.5 Mbp). The events leading up to this asymmetry probably occurred not that long ago in evolution, as there was not enough time to approach the natural tendency of a physical balance. Unlike the genomes of pathogenic species, the TM300 genome does not contain mobile elements such as plasmids, insertion sequences, transposons, or STAR elements; also, the number of repeat sequences is markedly decreased, suggesting a comparatively high stability of the genome. While most S. aureus genomes contain several prophages and genomic islands, the TM300 genome contains only one prophage, ΦTM300, and one genomic island, νSCA1, which is characterized by a mosaic structure mainly composed of species-specific genes. Most of the metabolic core pathways are present in the genome. Some open reading frames are truncated, which reflects the nutrient-rich environment of the meat starter culture, making some functions dispensable. The genome is well equipped with all functions necessary for the starter culture, such as nitrate/nitrite reduction, various sugar degradation pathways, two catalases, and nine osmoprotection systems. The genome lacks most of the toxins typical of S. aureus as well as genes involved in biofilm formation, underscoring the nonpathogenic status.

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 Dates: 2009-02
 Publication Status: Published in print
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 Identifiers: DOI: 10.1128/AEM.01982-08
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Title: Applied and Environmental Microbiology
  Other : Appl. Environ. Microbiol.
Source Genre: Journal
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Publ. Info: American Society for Microbiology (ASM)
Pages: - Volume / Issue: 75 (3) Sequence Number: - Start / End Page: 811 - 822 Identifier: ISSN: 0099-2240
CoNE: https://pure.mpg.de/cone/journals/resource/954927519600