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  Non-invasive monitoring of longitudinal changes in cerebral hemodynamics in acute ischemic stroke using BOLD signal delay

Khalil, A., Villringer, K., Filleböck, V., Hu, J.-Y., Rocco, A., Fiebach, J. B., et al. (2020). Non-invasive monitoring of longitudinal changes in cerebral hemodynamics in acute ischemic stroke using BOLD signal delay. Journal of Cerebral Blood Flow and Metabolism, 40(1), 23-34. doi:10.1177/0271678X18803951.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-CFA9-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-707F-F
Genre: Journal Article

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 Creators:
Khalil, Ahmed1, 2, 3, Author              
Villringer, Kersten1, Author
Filleböck, Vivien1, Author
Hu, Jiun-Yiing1, Author
Rocco, Andrea1, 4, Author
Fiebach, Jochen B.1, Author
Villringer, Arno1, 2, 3, Author              
Affiliations:
1Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
4Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Blood-oxygen-level-dependent delay; Perfusion; Blood flow; Acute stroke; Resting-state functional MRI
 Abstract: Relative delays in blood-oxygen-level-dependent (BOLD) signal oscillations can be used to assess cerebral perfusion without using contrast agents. However, little is currently known about the utility of this method in detecting clinically relevant perfusion changes over time. We investigated the relationship between longitudinal BOLD delay changes, vessel recanalization, and reperfusion in 15 acute stroke patients with vessel occlusion examined within 24 h of symptom onset (D0) and one day later (D1). We created BOLD delay maps using time shift analysis of resting-state functional MRI data and quantified perfusion lesion volume changes (using the D1/D0 volume ratio) and severity changes (using a linear mixed model) over time. Between baseline and follow-up, BOLD delay lesions shrank (median D1/D0 ratio = 0.2, IQR = 0.03–0.7) and BOLD delay severity decreased (b = −4.4 s) in patients with recanalization, whereas they grew (median D1/D0 ratio = 1.47, IQR = 1.1–1.7) and became more severe (b = 4.3 s) in patients with persistent vessel occlusion. Clinically relevant changes in cerebral perfusion in early stroke can be detected using BOLD delay, making this non-invasive method a promising option for detecting tissue at risk of infarction and monitoring stroke patients following recanalization therapy.

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Language(s): eng - English
 Dates: 2018-08-012018-04-182018-08-272018-10-182020-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1177/0271678X18803951
PMID: 30334657
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : 01EO0801 ; 01EO01301
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 40 (1) Sequence Number: - Start / End Page: 23 - 34 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202