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  Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly

Lampe, L., Kharabian, S., Kynast, J., Arélin, K., Steele, C., Löffler, M., et al. (2019). Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly. Journal of Cerebral Blood Flow and Metabolism, 39(1), 36-43. doi:10.1177/0271678X17740501.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-CFAF-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9670-5
Genre: Journal Article

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 Creators:
Lampe, Leonie1, 2, Author              
Kharabian, Shahrzad1, Author              
Kynast, Jana1, Author              
Arélin, Katrin1, Author              
Steele, Christopher1, 3, Author              
Löffler, Markus4, Author
Witte, A. Veronica1, Author              
Schroeter, Matthias L.1, 2, Author              
Villringer, Arno1, 2, Author              
Bazin, Pierre-Louis1, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montréal, QC, Cananda, ou_persistent22              
4Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              

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Free keywords: White matter hyperintensities; cerebral small vessel disease; cognitive impairment; brain atrophy; brain aging
 Abstract: White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort (n = 702, age range 60 – 82 years, mean age = 69.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter—including the corticospinal tract—compromised motor speed performance. This study exposes the subtle and subclinical yet detrimental effects of WMH on cognition in healthy elderly, and strongly suggests a causal influence of WMH on cognition by demonstrating the spatial specificity of these effects.

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Language(s): eng - English
 Dates: 2017-09-142017-06-192017-09-182017-11-062019-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1177/0271678X17740501
PMID: 29106319
PMC: PMC6311671
Other: Epub 2017
 Degree: -

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Funding organization : European Union (EU)
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
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Funding organization : Free State of Saxony
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Funding organization : LIFE – Leipzig Research Center for Civilization Diseases at the University of Leipzig
Project name : Obesity Mechanisms / SFB 1052
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Funding organization : German Research Foundation (DFG)
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Funding organization : Max-Planck International Research Network on Aging (MaxNetAging)

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 39 (1) Sequence Number: - Start / End Page: 36 - 43 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202