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  Right time, right place-DNA damage and DNA replication checkpoints collectively safeguard S phase

Galanti, L., & Pfander, B. (2018). Right time, right place-DNA damage and DNA replication checkpoints collectively safeguard S phase. EMBO Journal, 37(21): e100681. doi:10.15252/embj.2018100681.

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e100681.full.pdf (Publisher version), 214KB
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 Creators:
Galanti, Lorenzo1, Author              
Pfander, Boris1, Author              
Affiliations:
1Pfander, Boris / DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565165              

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Free keywords: PHOSPHORYLATION; ACTIVATION; INTEGRITY; RAD53; FORKBiochemistry & Molecular Biology; Cell Biology;
 Abstract: The DNA replication checkpoint (DRC) and the DNA damage checkpoint (DDC) are two closely linked signaling cascades that adjust S phase to the presence of DNA lesions and other replication impediments. Two recent studies published in The EMBO Journal shed new light on their relationship in budding yeast, collectively showing that the two pathways-while sharing several factors-differ in the location and kinetics of their activation, suggesting that they constitute different branches of an integrated cellular response to impaired DNA replication.

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Language(s): eng - English
 Dates: 2018-10-04
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000449944900006
DOI: 10.15252/embj.2018100681
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Title: EMBO Journal
  Other : EMBO J.
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 37 (21) Sequence Number: e100681 Start / End Page: - Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061