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  Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus

Habig, M., Kema, G. H. J., & Stukenbrock, E. H. (2018). Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus. eLife, 7: e40251. doi:10.7554/eLife.40251.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-D52C-D Version Permalink: http://hdl.handle.net/21.11116/0000-0002-D52D-C
Genre: Journal Article

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https://elifesciences.org/articles/40251 (Publisher version)
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 Creators:
Habig, Michael1, Author              
Kema, Gert H. J., Author
Stukenbrock, Eva Holtgrewe1, Author              
Rokas, Antonis, Contributor
Weigel, Detlef, Contributor
Affiliations:
1Max Planck Fellow Group Environmental Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068284              

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Free keywords: B chromosome, accessory chromosome, tetrad analysis, meiotic drive, selfish genetic elements, Zymoseptoria tritici
 Abstract: Meiosis is a key cellular process of sexual reproduction that includes pairing of homologous sequences. In many species however, meiosis can also involve the segregation of supernumerary chromosomes, which can lack a homolog. How these unpaired chromosomes undergo meiosis is largely unknown. In this study we investigated chromosome segregation during meiosis in the haploid fungus Zymoseptoria tritici that possesses a large complement of supernumerary chromosomes. We used isogenic whole chromosome deletion strains to compare meiotic transmission of chromosomes when paired and unpaired. Unpaired chromosomes inherited from the male parent as well as paired supernumerary chromosomes in general showed Mendelian inheritance. In contrast, unpaired chromosomes inherited from the female parent showed non-Mendelian inheritance but were amplified and transmitted to all meiotic products. We concluded that the supernumerary chromosomes of Z. tritici show a meiotic drive and propose an additional feedback mechanism during meiosis, which initiates amplification of unpaired female-inherited chromosomes.

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Language(s): eng - English
 Dates: 2018-07-202018-12-132018-12-132018
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.7554/eLife.40251
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 7 Sequence Number: e40251 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X