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  Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis

Franke, J., Kim, J., Hamilton, J. P., Zhao, D., Pham, G. M., Wiegert-Rininger, K., et al. (2019). Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis. Chembiochem, 20(1), 83-87. doi:10.1002/cbic.201800592.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-D8AF-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-3A60-A
Genre: Journal Article

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SOC076s1.pdf (Supplementary material), 2MB
 
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 Creators:
Franke, Jakob, Author
Kim, Jeongwoon, Author
Hamilton, John P., Author
Zhao, Dongyan, Author
Pham, Gina M., Author
Wiegert-Rininger, Krystle, Author
Crisovan, Emily, Author
Newton, Linsey, Author
Vaillancourt, Brieanne, Author
Tatsis, Evangelos, Author
Buell, C. Robin, Author
O'Connor, Sarah E.1, Author           
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Genome mining is a routine technique in microbes for discovering biosynthetic pathways. In plants, however, genomic information
is not commonly used to identify novel biosynthesis
genes. Here, we present the genome of the medicinal plant
and oxindole monoterpene indole alkaloid (MIA) producer Gelsemium
sempervirens (Gelsemiaceae). A gene cluster from Catharanthus
roseus, which is utilized at least six enzymatic steps
downstream from the last common intermediate shared between
the two plant alkaloid types, is found in G. sempervirens,
although the corresponding enzymes act on entirely different
substrates. This study provides insights into the common genomic
context of MIA pathways and is an important milestone
in the further elucidation of the Gelsemium oxindole alkaloid pathway.

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 Dates: 2018-09-092019
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: Other: SOC076
DOI: 10.1002/cbic.201800592
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Title: Chembiochem
  Other : Chembiochem
Source Genre: Journal
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Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: - Volume / Issue: 20 (1) Sequence Number: - Start / End Page: 83 - 87 Identifier: ISSN: 1439-4227
CoNE: https://pure.mpg.de/cone/journals/resource/110978984568897