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  Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking

Cohen, S., Rambold, A., & Lippincott-Schwartz, J. (2018). Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking. Molecular and Cellular Oncology, 5, e1043038. doi:10.1080/23723556.2015.1043038.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6DE5-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E36A-5
Genre: Journal Article

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 Creators:
Cohen, Sarah1, Author
Rambold, Angelika2, Author              
Lippincott-Schwartz, Jennifer1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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Free keywords: autophagy, fatty acid, lipase, lipid droplet, lipophagy, Mfn1, mitochondria, Opa1, tumor metabolism, tumor-stroma interactions
 Abstract: Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were replenished with FAs supplied by autophagy. These findings have important implications for cancer.

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Language(s): eng - English
 Dates: 20152018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1080/23723556.2015.1043038
 Degree: -

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Title: Molecular and Cellular Oncology
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: e1043038 Identifier: -