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  A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia

Adhikari, K., Mendoza-Revilla, J., Sohail, A., Fuentes-Guajardo, M., Lampert, J., Chacón-Duque, J. C., et al. (2019). A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia. Nature Communications, 10: 358. doi:10.1038/s41467-018-08147-0.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-DE1A-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-E0B6-3
Genre: Journal Article

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 Creators:
Adhikari, Kaustubh, Author
Mendoza-Revilla, Javier, Author
Sohail, Anood, Author
Fuentes-Guajardo, Macarena, Author
Lampert, Jodie, Author
Chacón-Duque, Juan Camilo, Author
Hurtado, Malena, Author
Villegas, Valeria, Author
Granja, Vanessa, Author
Acuña-Alonzo, Victor, Author
Jaramillo, Claudia, Author
Arias, William, Author
Barquera Lozano, Rodrigo José1, Author              
Everardo, Paola, Author
Gómez-Valdés, Jorge, Author
Villamil-Ramírez, Hugo, Author
Silva de Cerqueira, Caio Cesar, Author
Hunemeier, Tábita, Author
Ramallo, Virginia, Author
Schuler-Faccini, Lavinia, Author
Salzano, Francisco M., AuthorGonzalez-José, Rolando, AuthorBortolini, Maria-Cátira, AuthorCanizales-Quinteros, Samuel, AuthorGallo, Carla, AuthorPoletti, Giovanni, AuthorBedoya, Gabriel, AuthorRothhammer, Francisco, AuthorTobin, Desmond J., AuthorFumagalli, Matteo, AuthorBalding, David, AuthorRuiz-Linares, Andrés, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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 Abstract: We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation (in 10q26) and three novel loci for eye pigmentation (in 1q32, 20q13 and 22q12). We demonstrate the presence of multiple independent signals of association in the 11q14 and 15q13 regions (comprising the GRM5/TYR and HERC2/OCA2 genes, respectively) and several epistatic interactions among independently associated alleles. Strongest association with skin pigmentation at 19p13 was observed for an Y182H missense variant (common only in East Asians and Native Americans) in MFSD12, a gene recently associated with skin pigmentation in Africans. We show that the frequency of the derived allele at Y182H is significantly correlated with lower solar radiation intensity in East Asia and infer that MFSD12 was under selection in East Asians, probably after their split from Europeans.

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Language(s): eng - English
 Dates: 2019-01-21
 Publication Status: Published online
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41467-018-08147-0
Other: shh1162
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 10 Sequence Number: 358 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723