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  Psychiatry: Insights into depression through normative decision-making models

Huys, Q., Vogelstein, J., & Dayan, P. (2009). Psychiatry: Insights into depression through normative decision-making models. In D. Koller, D. Schuurmans, Y. Bengio, & L. Bottou (Eds.), Advances in Neural Information Processing Systems 21 (pp. 732-739). Red Hook, NY, USA: Curran.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-DE48-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0002-DE6F-9
Genre: Conference Paper

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 Creators:
Huys, QJM, Author
Vogelstein, JT, Author
Dayan, P1, Author           
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Decision making lies at the very heart of many psychiatric diseases. It is also a
central theoretical concern in a wide variety of fields and has undergone detailed,
in-depth, analyses. We take as an example Major Depressive Disorder (MDD),
applying insights from a Bayesian reinforcement learning framework. We focus
on anhedonia and helplessness. Helplessness—a core element in the conceptual-
izations of MDD that has lead to major advances in its treatment, pharmacolog-
ical and neurobiological understanding—is formalized as a simple prior over the
outcome entropy of actions in uncertain environments. Anhedonia, which is an
equally fundamental aspect of the disease, is related to the effective reward size.
These formulations allow for the design of specific tasks to measure anhedonia
and helplessness behaviorally. We show that these behavioral measures capture
explicit, questionnaire-based cognitions. We also provide evidence that these tasks
may allow classification of subjects into healthy and MDD groups based purely
on a behavioural measure and avoiding any verbal reports.

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 Dates: 2009-06
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: -
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Title: Twenty-Second Annual Conference on Neural Information Processing Systems (NIPS 2008)
Place of Event: Vancouver, BC, Canada
Start-/End Date: 2008-12-08 - 2008-12-10

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Title: Advances in Neural Information Processing Systems 21
Source Genre: Proceedings
 Creator(s):
Koller, D, Editor
Schuurmans, D, Editor
Bengio, Y, Editor
Bottou, L, Editor
Affiliations:
-
Publ. Info: Red Hook, NY, USA : Curran
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 732 - 739 Identifier: ISBN: 978-1-60560-949-2