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  Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults

Schaare, H. L., Kharabian, S., Beyer, F., Kumral, D., Uhlig, M., Reinelt, J., et al. (2019). Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults. Neurology, 92(8), e758-e773. doi:10.1212/WNL.0000000000006947.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E0E6-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-94B2-C
Genre: Journal Article

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 Creators:
Schaare, Herma Lina1, 2, Author              
Kharabian, Shahrzad1, Author              
Beyer, Frauke1, 3, Author              
Kumral, Deniz1, 4, Author              
Uhlig, Marie1, 2, Author
Reinelt, Janis1, Author              
Reiter, Andrea1, 5, Author              
Lampe, Leonie1, Author              
Babayan, Anahit1, 4, Author              
Erbey, Miray1, 4, Author              
Röbbig, Josefin1, Author              
Schroeter, Matthias L.1, 6, 7, Author              
Okon-Singer, Hadas8, Author              
Mueller, Karsten9, Author              
Mendes, Natacha10, Author              
Margulies, Daniel S.10, Author              
Witte, A. Veronica1, 3, Author              
Gaebler, Michael1, 4, 5, Author              
Villringer, Arno1, 3, 4, 5, 7, 11, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2International Max Planck Research School on Neuroscience of Communication, Leipzig, Germany, ou_persistent22              
3Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
4MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Lifespan Developmental Neuroscience, Department of Biological Psychology, Faculty of Psychology, TU Dresden, Germany, ou_persistent22              
6Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
8Department of Psychology, University of Haifa, Israel, ou_persistent22              
9Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634558              
10Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
11Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

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 Abstract: Objective To test whether elevated blood pressure (BP) relates to gray matter (GM) volume (GMV) changes in young adults who had not previously been diagnosed with hypertension (systolic BP [SBP]/diastolic BP [DBP] ≥140/90 mm Hg). Methods We associated BP with GMV from structural 3T T1-weighted MRI of 423 healthy adults between 19 and 40 years of age (mean age 27.7 ± 5.3 years, 177 women, SBP/DBP 123.2/73.4 ± 12.2/8.5 mm Hg). Data originated from 4 previously unpublished cross-sectional studies conducted in Leipzig, Germany. We performed voxel-based morphometry on each study separately and combined results in image-based meta-analyses (IBMA) to assess cumulative effects across studies. Resting BP was assigned to 1 of 4 categories: (1) SBP <120 and DBP <80 mm Hg, (2) SBP 120–129 or DBP 80–84 mm Hg, (3) SBP 130–139 or DBP 85–89 mm Hg, (4) SBP ≥140 or DBP ≥90 mm Hg. Results IBMA yielded the following results: (1) lower regional GMV was correlated with higher peripheral BP; (2) lower GMV was found with higher BP when comparing individuals in subhypertensive categories 3 and 2, respectively, to those in category 1; (3) lower BP-related GMV was found in regions including hippocampus, amygdala, thalamus, frontal, and parietal structures (e.g., precuneus). Conclusion BP ≥120/80 mm Hg was associated with lower GMV in regions that have previously been related to GM decline in older individuals with manifest hypertension. Our study shows that BP-associated GM alterations emerge continuously across the range of BP and earlier in adulthood than previously assumed. This suggests that treating hypertension or maintaining lower BP in early adulthood might be essential for preventing the pathophysiologic cascade of asymptomatic cerebrovascular disease to symptomatic end-organ damage, such as stroke or dementia.

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Language(s): eng - English
 Dates: 2018-01-092018-10-152019-01-232019-02-19
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1212/WNL.0000000000006947
PMID: 30674602
Other: Epub 2019
 Degree: -

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Title: Neurology
Source Genre: Journal
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Publ. Info: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Pages: - Volume / Issue: 92 (8) Sequence Number: - Start / End Page: e758 - e773 Identifier: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073