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  Gadolinium(III)‐Based Dual 1H/19F Magnetic Resonance Imaging Probes

Pujales-Paradela, R., Savić, T., Esteban-Gomez, D., Angelovski, G., Carniato, F., Botta, M., et al. (2019). Gadolinium(III)‐Based Dual 1H/19F Magnetic Resonance Imaging Probes. Chemistry – A European Journal, 25(18), 4782-4792. doi:10.1002/chem.201806192.

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Pujales-Paradela, R, Autor
Savić, T1, 2, Autor           
Esteban-Gomez, D, Autor
Angelovski, G1, 2, Autor           
Carniato, F, Autor
Botta, M, Autor
Platas-Iglesias, C, Autor
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              

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 Zusammenfassung: We present two novel octadentate cyclen-based ligands containing one (L1) or two (L2) phenylacetamide pendants that feature two CF3 groups either at positions 3 and 5 (L1) or 4 (L2). The corresponding Gd3+ complexes possess one coordinated water molecule, as confirmed by the luminescence lifetime measurements recorded on the Eu(III) and Tb(III) analogues. A detailed 1H and 17O relaxometric characterisation revealed the parameters that govern the relaxivities of these complexes. The water exchange rate of the mono-amide derivative GdL1 (kex298 = 1.52×106 s-1) is faster than that determined for the bis-amide complex GdL2 (kex298 = 0.73×106 s-1). 1H and 19F NMR studies indicate that the complexes are present in solution almost exclusively as the square antiprismatic (SAP) isomers. 19F NMR relaxation studies provided Gd···F distances of 7.4 + 0.1 and 9.1 + 0.1 Å for GdL1 and GdL2, respectively. Phantom MRI studies revealed the favourable properties of GdL2 as a dual 1H/19F MRI probe, while the shorter Gd···F distance of GdL1 reduces the signal to noise ratio due to the very short transverse relaxation time of the 19F NMR signal.

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 Datum: 2019-012019-03
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1002/chem.201806192
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Titel: Chemistry – A European Journal
  Andere : Chem. – Eur. J.
  Andere : Chem. Eur. J.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Weinheim : Wiley-VCH
Seiten: - Band / Heft: 25 (18) Artikelnummer: - Start- / Endseite: 4782 - 4792 Identifikator: ISSN: 0947-6539
CoNE: https://pure.mpg.de/cone/journals/resource/954926979058