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  Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin

Sanin, D. E., Matsushita, M., Klein-Geltink, R., Grzes, K., van Bakker, N. T., Corrado, M., et al. (2018). Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin. Immunity, 49, 1021-1033. doi:org/10.1016/j.immuni.2018.10.011.

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 Creators:
Sanin, David E.1, Author
Matsushita, Mai1, Author
Klein-Geltink, Ramon1, Author              
Grzes, Katarzyna1, Author              
van Bakker, Nikki Teijlingen1, Author
Corrado, Mauro1, Author              
Kabat, Agnieska1, Author              
Buck, Michael D.1, 2, Author
Qiu, Jing1, 2, Author
Lawless, Simon J.1, Author
Cameron, Alana1, Author
Villa, Matteo1, Author              
Baixauli Celda, Francesc1, Author              
Patterson, Annette E.1, Author
Hässler, Fabian1, Author
Curtis, Jonathan D.1, Author
O’Neill, Christina M.2, Author
O'Sullivan, David1, Author              
Wu, Duojiao2, Author
Mittler, Gerhard1, Author              
Huang, Stanley Ching-Cheng1, AuthorPearce, Erika L.1, Author              Pearce, Edward J.1, Author               more..
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
2External Organizations, ou_persistent22              

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 Abstract: Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effects on Δψm were a consequence of PGE2-initiated transcriptional regulation of genes, particularly Got1, in the malate-aspartate shuttle (MAS). Reduced Δψm caused alterations in the expression of 126 voltage-regulated genes (VRGs), including those encoding resistin-like molecule α (RELMα), a key marker of M(IL-4) cells, and genes that regulate the cell cycle. The transcription factor ETS variant 1 (ETV1) played a role in the regulation of 38% of the VRGs. These results reveal ETV1 as a Δψm-sensitive transcription factor and Δψm as a mediator of mitochondrial-directed nuclear gene expression.

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Language(s): eng - English
 Dates: 2018-12-18
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: org/10.1016/j.immuni.2018.10.011
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Title: Immunity
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 49 Sequence Number: - Start / End Page: 1021 - 1033 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783