English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin

Sanin, D. E., Matsushita, M., Klein-Geltink, R., Grzes, K., van Bakker, N. T., Corrado, M., et al. (2018). Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin. Immunity, 49, 1021-1033. doi:org/10.1016/j.immuni.2018.10.011.

Item is

Files

show Files
hide Files
:
Sanin et al..pdf (Publisher version), 5MB
 
File Permalink:
-
Name:
Sanin et al..pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Immunobiology and Epigenetics, MFIB; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Sanin, David E.1, Author
Matsushita, Mai1, Author
Klein-Geltink, Ramon1, Author           
Grzes, Katarzyna1, Author           
van Bakker, Nikki Teijlingen1, Author
Corrado, Mauro1, Author           
Kabat, Agnieska1, Author           
Buck, Michael D.1, 2, Author
Qiu, Jing1, 2, Author
Lawless, Simon J.1, Author
Cameron, Alana1, Author
Villa, Matteo1, Author           
Baixauli Celda, Francesc1, Author           
Patterson, Annette E.1, Author
Hässler, Fabian1, Author
Curtis, Jonathan D.1, Author
O’Neill, Christina M.2, Author
O'Sullivan, David1, Author           
Wu, Duojiao2, Author
Mittler, Gerhard1, Author           
Huang, Stanley Ching-Cheng1, AuthorPearce, Erika L.1, Author           Pearce, Edward J.1, Author            more..
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effects on Δψm were a consequence of PGE2-initiated transcriptional regulation of genes, particularly Got1, in the malate-aspartate shuttle (MAS). Reduced Δψm caused alterations in the expression of 126 voltage-regulated genes (VRGs), including those encoding resistin-like molecule α (RELMα), a key marker of M(IL-4) cells, and genes that regulate the cell cycle. The transcription factor ETS variant 1 (ETV1) played a role in the regulation of 38% of the VRGs. These results reveal ETV1 as a Δψm-sensitive transcription factor and Δψm as a mediator of mitochondrial-directed nuclear gene expression.

Details

show
hide
Language(s): eng - English
 Dates: 2018-12-18
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: org/10.1016/j.immuni.2018.10.011
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Immunity
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 49 Sequence Number: - Start / End Page: 1021 - 1033 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783