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  Reduced bonobo MHC class I diversity predicts a reduced viral peptide binding ability compared to chimpanzees

Maibach, V., & Vigilant, L. (2019). Reduced bonobo MHC class I diversity predicts a reduced viral peptide binding ability compared to chimpanzees. BMC Evolutionary Biology, 19: 14. doi:10.1186/s12862-019-1352-0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-E3B9-D Version Permalink: https://hdl.handle.net/21.11116/0000-0002-E420-8
Genre: Journal Article

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Maibach_Reduced_BMCEvoBio_2019.pdf (Publisher version), 3MB
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2019
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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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 Creators:
Maibach, Vincent1, 2, Author           
Vigilant, Linda3, Author           
Affiliations:
1Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_1497674              
2The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society, Deutscher Platz 6, 04103 Leipzig, DE, ou_1497688              
3Molecular Genetics Laboratory, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2149639              

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Free keywords: Pan paniscus, Pan troglodytes, Great apes, NetMHCpan, Major histocompatibility complex
 Abstract: The highly polymorphic genes of the major histocompatibility complex (MHC) class I are involved in defense against viruses and other intracellular pathogens. Although several studies found reduced MHC class I diversity in bonobos in comparison to the closely related chimpanzee, it is unclear if this lower diversity also influences the functional ability of MHC class I molecules in bonobos. Here, we use a bioinformatic approach to analyze the viral peptide binding ability of all published bonobo MHC class I molecules (n =þinspace}58) in comparison to all published chimpanzee MHC class I molecules (n ={þinspace161) for the class I loci A, B, C and A-like.

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Language(s): eng - English
 Dates: 2019-01-10
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1186/s12862-019-1352-0
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Title: BMC Evolutionary Biology
Source Genre: Journal
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Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 19 Sequence Number: 14 Start / End Page: - Identifier: ISSN: 1471-2148