English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Ca2+ signals in astrocytes facilitate spread of epileptiform activity

Heuser, K., Nome, C. G., Pettersen, K. H., Åbjørsbråten, K. S., Jensen, V., Tang, W., et al. (2018). Ca2+ signals in astrocytes facilitate spread of epileptiform activity. Cerebral Cortex, 28(11), 4036-4048. doi:10.1093/cercor/bhy196.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E3C4-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-E3C5-F
Genre: Journal Article

Files

show Files
hide Files
:
CerebCortex_28_2018_4036.pdf (Any fulltext), 965KB
 
File Permalink:
-
Name:
CerebCortex_28_2018_4036.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
https://doi.org/10.1093/cercor/bhy196 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Heuser, Kjell, Author
Nome, Cecilie G., Author
Pettersen, Klas H., Author
Åbjørsbråten, Knut S., Author
Jensen, Vidar, Author
Tang, Wannan, Author
Sprengel, Rolf1, Author              
Taubøll, Erik, Author
Nagelhus, Erlend A., Author
Enger, Rune, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: -
 Abstract: Epileptic seizures are associated with increased astrocytic Ca2+ signaling, but the fine spatiotemporal kinetics of the ictal astrocyte-neuron interplay remains elusive. By using 2-photon imaging of awake head-fixed mice with chronic hippocampal windows we demonstrate that astrocytic Ca2+ signals precede neuronal Ca2+ elevations during the initial bout of kainate-induced seizures. On average, astrocytic Ca2+ elevations preceded neuronal activity in CA1 by about 8 s. In subsequent bouts of epileptic seizures, astrocytes and neurons were activated simultaneously. The initial astrocytic Ca2+ elevation was abolished in mice lacking the type 2 inositol-1,4,5-trisphosphate-receptor (Itpr2-/-). Furthermore, we found that Itpr2-/- mice exhibited 60% less epileptiform activity compared with wild-type mice when assessed by telemetric EEG monitoring. In both genotypes we also demonstrate that spreading depression waves may play a part in seizure termination. Our findings imply a role for astrocytic Ca2+ signals in ictogenesis.

Details

show
hide
Language(s): eng - English
 Dates: 2018-08-312018-11-012018-11-01
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 28 (11) Sequence Number: - Start / End Page: 4036 - 4048 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440