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  The human habenula is responsive to changes in luminance and circadian rhythm

Kaiser, C., Kaufmann, C., Leutritz, T., Arnold, Y. L., Speck, O., & Ullsperger, M. (2019). The human habenula is responsive to changes in luminance and circadian rhythm. NeuroImage, 189, 581-588. doi:10.1016/j.neuroimage.2019.01.064.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E453-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8907-B
Genre: Journal Article

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1-s2.0-S1053811919300709-main.pdf (Preprint), 2MB
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2019-01-28
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 Creators:
Kaiser, Christian1, Author
Kaufmann, Christian1, 2, Author
Leutritz, Tobias3, 4, Author              
Arnold, Yan Louis3, Author
Speck, Oliver3, 5, 6, 7, Author
Ullsperger, Markus1, 7, Author
Affiliations:
1Department of Neuropsychology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
2Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
3Department of Biomedical Magnetic Resonance, Institute of Experimental Physics, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Leibniz Institute for Neurobiology, Magdeburg, Germany, ou_persistent22              
6German Center for Neurodegenerative Diseases, Magdeburg, Germany, ou_persistent22              
7Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              

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Free keywords: Human habenula; Luminance; Circadian rhythm; fMRI
 Abstract: The habenula is a pivotal structure in the neural network that implements various forms of cognitive and motivational functions and behaviors. Moreover, it has been suggested to be part of the brain's circadian system, not at least because habenular neurons are responsive to retinal illumination and exhibit circadian modulations of their firing patterns in animal research. However, no study has directly investigated the human habenula in this regard. We developed a paradigm in which alternating phases of high and low luminance are used to study human habenular functioning. In two experiments with independent samples, fMRI data of 24 healthy participants were acquired at a field strength of 7T, and of 21 healthy participants at 3T. Region of interest analyses revealed that the human habenula is responsive to light as well, resulting in a decrease in activation when a change in luminance occurs. Although this pattern is not predicted by animal research, we were able to replicate this finding in a second independent data set. Furthermore, we demonstrate that the strength of decrease in activation is modulated in a circadian fashion, being more strongly deactivated in morning than in afternoon sessions. Taken together, these findings provide strong evidence that changes in illumination elicit changes in habenular activation and that these changes appear to be more pronounced in the morning than in the afternoon.

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Language(s): eng - English
 Dates: 2018-12-242018-10-042019-01-252019-01-282019-04-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2019.01.064
PII: S1053-8119(19)30070-9
PMID: 30703517
Other: Epub ahead of print
 Degree: -

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Project name : Neurobiologie motivierten Verhaltens / SFB 779
Grant ID : 15.0137
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 189 Sequence Number: - Start / End Page: 581 - 588 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166