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  Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories

Gerhauser, C., Favero, F., Risch, T., Simon, R., Feuerbach, L., Assenov, Y., et al. (2018). Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. Cancer Cell, 34(6), 996-1011. doi:10.1016/j.ccell.2018.10.016.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E51A-F Version Permalink: http://hdl.handle.net/21.11116/0000-0002-E51B-E
Genre: Journal Article

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© 2018 Gerhauser et al.

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 Creators:
Gerhauser, Clarissa , Author
Favero, Francesco , Author
Risch, Thomas1, Author              
Simon, Ronald, Author
Feuerbach, Lars, Author
Assenov, Yassen , Author
Heckmann, Doreen , Author
Sidiropoulos, Nikos , Author
Waszak, Sebastian M. , Author
Hübschmann, Daniel, Author
Urbanucci, Alfonso , Author
Girma, Etsehiwot G. , Author
Kuryshev, Vladimir , Author
Klimczak, Leszek J. , Author
Saini, Natalie , Author
Stütz, Adrian M. , Author
Weichenhan, Dieter , Author
Böttcher, Lisa-Marie , Author
Toth, Reka, Author
Hendriksen, Josephine D. , Author
Koop, Christina, AuthorLutsik, Pavlo , AuthorMatzk, Sören , AuthorWarnatz, Hans-Jörg1, Author              Amstislavskiy, Vyacheslav1, Author              Feuerstein, Clarissa, AuthorRaeder, Benjamin , AuthorBogatyrova, Olga , AuthorSchmitz, Eva-Maria, AuthorHube-Magg, Claudia , AuthorKluth, Martina, AuthorHuland, Hartwig , AuthorGraefen, Markus, AuthorLawerenz, Chris, AuthorHenry, Gervaise H. , AuthorYamaguchi, Takafumi N. , AuthorMalewska, Alicia , AuthorMeiners, Jan, AuthorSchilling, Daniela , AuthorReisinger, Eva, AuthorEils, Roland, AuthorSchlesner, Matthias , AuthorStrand, Douglas W. , AuthorBristow, Robert G. , AuthorBoutros, Paul C. , Authorvon Kalle, Christof , AuthorGordenin, Dmitry , AuthorSültmann, Holger, AuthorBrors, Benedikt , AuthorSauter, Guido , AuthorPlass, Christoph, AuthorYaspo, Marie-Laure1, Author              Korbel, Jan O. , AuthorSchlomm, Thorsten , AuthorWeischenfeldt, Joachim, Author more..
Affiliations:
1Gene Regulation and Systems Biology of Cancer (Marie-Laure Yaspo), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117287              

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Free keywords: APOBEC; cancer genomics; early-onset cancer; epigenetic risk-score; mutational processes; prostate cancer; structural variants; tumor evolution; tumor evolution prediction
 Abstract: Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Our integrative analysis identified four molecular subgroups, including a particularly aggressive subgroup with recurrent duplications associated with increased expression of ESRP1, which we validate in 12,000 tissue microarray tumors. Finally, we combined the patterns of molecular co-occurrence and risk-based subgroup information to deconvolve the molecular and clinical trajectories of prostate cancer from single patient samples.

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Language(s): eng - English
 Dates: 2018-12-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.ccell.2018.10.016
 Degree: -

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Title: Cancer Cell
  Other : Cancer Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: 16 Volume / Issue: 34 (6) Sequence Number: - Start / End Page: 996 - 1011 Identifier: ISSN: 1535-6108
CoNE: https://pure.mpg.de/cone/journals/resource/111025129473004