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  Increased stability and breakdown of brain effective connectivity during slow-wave sleep: Mechanistic insights from whole-brain computational modelling

Jobst, B. M., Hindriks, R., Laufs, H., Tagliazucchi, E., Hahn, G., Ponce-Alvarez, A., et al. (2017). Increased stability and breakdown of brain effective connectivity during slow-wave sleep: Mechanistic insights from whole-brain computational modelling. Scientific Reports, 7: 4634. doi:10.1038/s41598-017-04522-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E5CC-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C1D9-E
Genre: Journal Article

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 Creators:
Jobst, Beatrice M. 1, Author
Hindriks, Rikkert 1, Author
Laufs, Helmut 1, Author
Tagliazucchi, Enzo 1, Author
Hahn, Gerald 1, Author
Ponce-Alvarez, Adrián 1, Author
Stevner, Angus B. A.1, Author
Kringelbach, Morten L. 1, Author
Deco, Gustavo1, 2, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Computational neuroscience; Computational science
 Abstract: Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a supercritical Hopf bifurcation and studied the dynamical changes when adapting the bifurcation parameter for all brain nodes to best match wakefulness and slow-wave sleep. Furthermore, we analysed differences in effective connectivity between the two states. In addition to significant changes in functional connectivity, synchrony and metastability, this analysis revealed a significant shift of the global dynamic working point of brain dynamics, from the edge of the transition between damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep. Moreover, we identified a significant global decrease in effective interactions during slow-wave sleep. These results suggest a mechanism for the empirical functional changes observed during slow-wave sleep, namely a global shift of the brain’s dynamic working point leading to increased stability and decreased effective connectivity.

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Language(s): eng - English
 Dates: 2017-02-022017-05-162017-07-05
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-017-04522-x
PMC: PMC5498661
PMID: 28680119
 Degree: -

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Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : How consciousness is shaped by neuronal network dynamics / CONSCBRAIN
Grant ID : 661583
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : PSI2013-42091 ; PSI2016-75688-P ; PCIN-2013-026
Funding program : Programa Estatal de Investigación Cientifica y Tecnica de Excelencia MINECO
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Grant ID : IJCI-2014-21066
Funding program : Juan de la Cierva fellowship
Funding organization : Spanish Research Agency (AEI)
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Grant ID : AGAUR 2014 SGR 856
Funding program : -
Funding organization : Generalitat de Catalunya
Project name : -
Grant ID : 01EV0703
Funding program : -
Funding organization : Deutsches Bundesministerium für Bildung und Forschung (BMBF)
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Grant ID : -
Funding program : -
Funding organization : ProLOEWE. Netzwerk der LOEWE-Forschungsvorhaben
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Funding program : -
Funding organization : AXA Foundation
Project name : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7
Funding organization : European Commission (EC)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 7 Sequence Number: 4634 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322