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  Multimodal assessment of recovery from coma in a rat model of diffuse brainstem tegmentum injury

Pais-Roldán, P., Edlow, B., Jiang, Y., Stelzer, J., Zou, M., & Yu, X. (2019). Multimodal assessment of recovery from coma in a rat model of diffuse brainstem tegmentum injury. NeuroImage, 189, 615-630. doi:10.1016/j.neuroimage.2019.01.060.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E95D-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-F79E-6
Genre: Journal Article

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Pais-Roldán, P1, 2, Author              
Edlow, BL, Author
Jiang, Y1, 2, Author              
Stelzer, J2, 3, Author              
Zou, M, Author
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Despite the association between brainstem lesions and coma, a mechanistic understanding of coma pathogenesis and recovery is lacking. We developed a coma model in the rat mimicking human brainstem coma, which allowed multimodal analysis of a brainstem tegmentum lesion's effects on behavior, cortical electrophysiology, and global brain functional connectivity. After coma induction, we observed a transient period (∼1h) of unresponsiveness accompanied by cortical burst-suppression. Comatose rats then gradually regained behavioral responsiveness concurrent with emergence of delta/theta-predominant cortical rhythms in primary somatosensory cortex. During the acute stage of coma recovery (∼1–8h), longitudinal resting-state functional MRI revealed an increase in functional connectivity between subcortical arousal nuclei in the thalamus, basal forebrain, and basal ganglia and cortical regions implicated in awareness. This rat coma model provides an experimental platform to systematically study network-based mechanisms of coma pathogenesis and recovery, as well as to test targeted therapies aimed at promoting recovery of consciousness after coma.

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 Dates: 2019-012019-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2019.01.060
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 189 Sequence Number: - Start / End Page: 615 - 630 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166