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  Perspectives for the use of neurotechnologies in conjunction with muscle autotransplantation in children

Blagovechtchenski, E., Agranovich, O., Kononova, Y., Nazarova, M., & Nikulin, V. V. (2019). Perspectives for the use of neurotechnologies in conjunction with muscle autotransplantation in children. Frontiers in Neuroscience, 13: 99. doi:10.3389/fnins.2019.00099.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-EB8A-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8E32-5
Genre: Journal Article

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 Creators:
Blagovechtchenski, Evgueni 1, Author
Agranovich, Olga 2, Author
Kononova, Yelisaveta 2, Author
Nazarova, Maria 1, 3, Author
Nikulin, Vadim V.1, 4, Author              
Affiliations:
1Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
2Turner Scientific Research Institute for Children's Orthopedics, Saint Petersburg, Russia, ou_persistent22              
3Federal Center for Cerebrovascular Pathology and Stroke, Ministry of Healthcare of the Russian Federation, Moscow, Russia, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Neurotechnologies; autotranslplantation; motor control; Arthrogryposis; Rehabilitation; Neuroprosthesis
 Abstract: Muscles autotransplantation is an important way to restore motor activity in case of injury or diseases associated with a loss of muscles ability. One of the typical examples of such pathology is arthrogryposis multiplex congenita (AMC). Arthrogryposis is one of the most serious congenital malformations of the musculoskeletal system. It is characterized by the presence of two or more major joint contractures, muscle damage, and motoneuronal dysfunction in the anterior horns of the spinal cord. One of the main problems that determines the limitation or even impossibility of self-care of patients suffering from arthrogryposis is the lack of active movements in the upper limb joints, which can be restored by autotransplantation of the muscles of various donor areas (Hall, 1997; Bamshad et al., 2009; Loeffler and Lewis, 2016). A major limiting factor for the adequate self-care in patients with this pathology is a lack of the active elbow flexion due to the fibro-fatty degeneration of the flexors of the forearm. Such deficits significantly affect the quality of life because many vital functions are associated with the elbow movements, for example, bringing food to the mouth. Thus, for these patients it is important to secure functional recovery of the biceps brachii muscle, which is performed by non-free (with preservation of the vascular-muscular bundle) autotransplantation of the muscles surrounding the shoulder joint (commonly by the pectoralis major or the latissimus dorsi muscles) (Oishi et al., 2017). The loss of the muscle function in the donor region does not cause any significant functional impairment due to the work of the remaining synergistic muscles (Mikati, 2007; Zargarbashi et al., 2017). There are two pivotal and non-trivial aspects witch should be addressed for such surgeries: 1. Which muscle is the most suitable for the autotransplantation? 2. How to facilitate the rehabilitation processes after the muscle autotransplantation? Next, we discuss these two issues in more detail.

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Language(s): eng - English
 Dates: 2018-11-102019-01-282019-02-15
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnins.2019.00099
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Funding program : HSE Basic Research Program
Funding organization : Health and Safety Executive (HSE)
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Funding program : Russian Academic Excellence Project 5–100
Funding organization : Ministry of Science and Higher Education of the Russian Federation

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 99 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548