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  An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole

Payne, R. M. E., Xu, D., Foureau, E., Carqueijeiro, M. I. S. T., Oudin, A., de Bernonville, T. D., et al. (2017). An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole. Nature, 3: 16208. doi:10.1038/nplants.2016.208.

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 Creators:
Payne, Richard M. E., Author
Xu, Deyang, Author
Foureau, Emilien, Author
Carqueijeiro, Marta Ines Soares Teto, Author
Oudin, Audrey, Author
de Bernonville, Thomas Dugé, Author
Novak, Vlastimil, Author
Burow, Meike, Author
Olsen, Carl-Erik, Author
Jones, D. Marc, Author
Tatsis, Evangelos C., Author
Pendle, Ali, Author
Halkier, Barbara Ann, Author
Geu-Flores, Fernando, Author
Courdavault, Vincent, Author
Nour-Eldin, Hussam Hassan, Author
O’Connor, Sarah E.1, Author           
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1External Organizations, ou_persistent22              

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 Abstract: Plants sequester intermediates of metabolic pathways into different cellular compartments, but the mechanisms by which these molecules are transported remain poorly understood. Monoterpene indole alkaloids, a class of specialized metabolites that includes the anticancer agent vincristine, antimalarial quinine and neurotoxin strychnine, are synthesized in several different cellular locations. However, the transporters that control the movement of these biosynthetic intermediates within cellular compartments have not been discovered. Here we present the discovery of a tonoplast localized nitrate/peptide family (NPF) transporter from Catharanthus roseus, CrNPF2.9, that exports strictosidine, the central intermediate of this pathway, into the cytosol from the vacuole. This discovery highlights the role that intracellular localization plays in specialized metabolism, and sets the stage for understanding and controlling the central branch point of this pharmacologically important group of compounds.

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 Dates: 2017-01-132017
 Publication Status: Published in print
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 Identifiers: Other: SOC086
DOI: 10.1038/nplants.2016.208
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 3 Sequence Number: 16208 Start / End Page: - Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238