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  When less is more: Structural correlates of core executive functions in young adults: A VBM and cortical thickness study

Weise, C. M., Bachmann, T., Schroeter, M. L., & Saur, D. (2019). When less is more: Structural correlates of core executive functions in young adults: A VBM and cortical thickness study. NeuroImage, 189, 896-903. doi:10.1016/j.neuroimage.2019.01.070.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-EF2F-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-88F5-F
Genre: Journal Article

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 Creators:
Weise, Christopher M.1, Author
Bachmann, Tobias1, Author
Schroeter, Matthias L.2, 3, Author              
Saur, Dorothee1, Author
Affiliations:
1Department of Neurology, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Executive functions; Cognitive flexibility; Inhibitory control; VBM; Cortical thickness
 Abstract: Background The term executive functions (EF) describes a set of higher cognitive abilities/skills needed for goal-oriented and flexible behavior. In contrast to a multitude of functional neuroimaging studies of EF performance, only limited and partially inconclusive data is available for the structural-neuroanatomical underpinnings of EFs, particularly in healthy adults. Methods Here, we applied voxel-based morphometry (VBM) and additional analyses of cortical thickness (CTH; via surface-based morphometry) to a large sample of healthy young adults from the Human Connectome Project (N = 1110; Age 28.8 ± 3.7 years) with structural MRI data and test data reflective of three core EFs [i.e. cognitive flexibility, inhibitory control and working memory]. Results For CF and IC, VBM analyses yielded a distinct and largely overlapping pattern of exclusively negative associations, most prominently within the medial prefrontal cortex, the insular cortex, central/precentral regions, subcortical and mesotemporal structures. A similar, yet less pronounced pattern of negative associations was found in analyses of CTH. In contrast, both VBM and CTH analyses yielded no significant associations with WM performance. Conclusions Brain regions we found negatively associated with measures of cognitive flexibility and inhibitory control have been repeatedly highlighted by functional imaging studies of EF performance. The here observed inverse relationship with brain structural parameters may be related to the young age of our study population and well established neurobiological mechanisms of cortical maturation (i.e. cortical thinning via synaptic pruning and cortical myelination).

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Language(s): eng - English
 Dates: 2018-12-302018-09-082019-01-282019-02-012019-04-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2019.01.070
PMID: 30716455
Other: Epub ahead of print
 Degree: -

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Project name : -
Grant ID : 1U54MH091657
Funding program : -
Funding organization : National Institute of Health (NIH)
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Grant ID : -
Funding program : -
Funding organization : McDonnell Center for Systems Neuroscience at Washington University

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 189 Sequence Number: - Start / End Page: 896 - 903 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166