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  Evolution of white matter tract microstructure across the life span

Slater, D. A., Melie‐Garcia, L., Preisig, M., Kherif, F., Lutti, A., & Draganski, B. (2019). Evolution of white matter tract microstructure across the life span. Human Brain Mapping, 40(7), 2252-2268. doi:10.1002/hbm.24522.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-EF3B-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-962C-3
Genre: Journal Article

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 Creators:
Slater, David A. 1, Author
Melie‐Garcia, Lester 1, Author
Preisig, Martin 2, Author
Kherif , Ferath 1, Author
Lutti, Antoine1, Author
Draganski, Bogdan1, 3, Author              
Affiliations:
1Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Aging; Degeneration; Development; Intracellular volume fraction (ICVF); Iron; Life span; Longitudinal (R1) and transverse (R2*); Relaxation rates; Mean diffusivity (MD); MRI; Myelin; Quantitative magnetic resonance imaging (qMRI); Tractography; White matter
 Abstract: The human brain undergoes dramatic structural change over the life span. In a large imaging cohort of 801 individuals aged 7–84 years, we applied quantitative relaxometry and diffusion microstructure imaging in combination with diffusion tractography to investigate tissue property dynamics across the human life span. Significant nonlinear aging effects were consistently observed across tracts and tissue measures. The age at which white matter (WM) fascicles attain peak maturation varies substantially across tissue measurements and tracts. These observations of heterochronicity and spatial heterogeneity of tract maturation highlight the importance of using multiple tissue measurements to investigate each region of the WM. Our data further provide additional quantitative evidence in support of the last‐in‐first‐out retrogenesis hypothesis of aging, demonstrating a strong correlational relationship between peak maturational timing and the extent of quadratic measurement differences across the life span for the most myelin sensitive measures. These findings present an important baseline from which to assess divergence from normative aging trends in developmental and degenerative disorders, and to further investigate the mechanisms connecting WM microstructure to cognition.

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Language(s): eng - English
 Dates: 2018-12-282018-07-052019-01-022019-01-232019-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.24522
PMID: 30673158
Other: Epub ahead of print
 Degree: -

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Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
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Funding organization : GlaxoSmithKline
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Funding organization : Faculty of Biology and Medicine, University of Lausanne
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Grant ID : 3200B0–105993
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Funding organization : Swiss National Science Foundation
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Grant ID : 3200B0‐118308
Funding program : -
Funding organization : Swiss National Science Foundation
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Grant ID : 33CSCO‐122661
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Funding organization : Swiss National Science Foundation
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Grant ID : 33CS30‐139468
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Funding organization : Swiss National Science Foundation
Project name : -
Grant ID : 33CS30‐148401
Funding program : -
Funding organization : Swiss National Science Foundation
Project name : NCCR Synapsy
Grant ID : 32003B_159780
Funding program : -
Funding organization : Swiss National Science Foundation
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Funding program : -
Funding organization : Fondation Leenaards
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Funding organization : Roger De Spoelberch Foundation
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Funding program : -
Funding organization : Partridge Foundation

Source 1

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Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 40 (7) Sequence Number: - Start / End Page: 2252 - 2268 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686