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  Subcortical Shape Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group

Ho, T., Gutman, B., Pozzi, E., Grabe, H., Hosten, N., Wittfeld, K., et al. (submitted). Subcortical Shape Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-F0BB-C Version Permalink: http://hdl.handle.net/21.11116/0000-0002-F0BC-B
Genre: Journal Article

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 Creators:
Ho, TC, Author
Gutman, B, Author
Pozzi, E, Author
Grabe, HJ, Author
Hosten, N, Author
Wittfeld, K, Author
Völzke, H, Author
Baune, B, Author
Dannlowski, U, Author
Förster, K, Author
Grotegerd, D, Author
Redlich, R, Author
Jansen, A, Author
Kircher, T, Author
Krug, A, Author
Meinert, S, Author
Nenadic, I, Author
Opel, N, Author
Dinga, R, Author
Veltman, DJ, Author
Schnell, K, AuthorVeer, I, AuthorWalter, H, AuthorGotlib, IH, AuthorSacchet, MD, AuthorAleman, A, AuthorGroenewold, NA, AuthorStein, DJ, AuthorLi, M1, 2, Author              Walter, M, Author              Jahanshad, N, AuthorThompson, PM, AuthorSämann, PG, AuthorSchmaal, L, Author more..
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Alterations in regional subcortical brain volumes have been widely investigated as part of the efforts of an international consortium, ENIGMA, to determine reliable structural brain signatures for Major Depressive Disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work to precisely map localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus. Harmonized data processing and statistical analyses were conducted locally at each site, and findings were aggregated by meta-analysis. Relative to CTL, patients with MDD had lower surface area in the subiculum of the hippocampus, the basolateral amygdala, and the nucleus accumbens shell. Relative to CTL, patients with adolescent-onset MDD (≤ 21 years) had lower thickness and surface area of the subiculum of the hippocampus and the basolateral amygdala. Relative to first-episode MDD, recurrent MDD patients had lower thickness and surface area in the CA1 of the hippocampus and the basolateral amygdala. Our results suggest that previously reported MDD-associated volumetric differences may be localized to specific subfields of these structures that have been shown to be sensitive to the effects of stress, with important implications for mapping treatments to patients based on specific neural targets and key clinical features.

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 Dates: 2019-02
 Publication Status: Submitted
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 Identifiers: DOI: 10.1101/534370
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