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  Compartmentalised RNA catalysis in membrane-free coacervate protocells

Drobot, B., Iglesias Artola, J. M., Le Vay, K., Mayr, V., Kar, M., Kreysing, M., et al. (2018). Compartmentalised RNA catalysis in membrane-free coacervate protocells. Nature Communications, 9: 3643. doi:10.1038/s41467-018-06072-w.

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Drobot, Björn1, Author
Iglesias Artola, Juan Manuel1, Author           
Le Vay, Kristian2, Author           
Mayr, Viktoria2, Author           
Kar, Mrityunjoy1, Author           
Kreysing, Moritz1, Author           
Mutschler, Hannes2, Author           
Tang, T-Y Dora1, Author           
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1External Organizations, ou_persistent22              
2Mutschler, Hannes / Biomimetic Systems, Max Planck Institute of Biochemistry, Max Planck Society, ou_2466697              

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Free keywords: Biophysics; Chemistry; Materials science
 Abstract: Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via complex coacervation, which may have been important for driving primitive reactions as part of the RNA world hypothesis. However, to date, RNA catalysis has not been reconciled with coacervation. Here we demonstrate that RNA catalysis is viable within coacervate microdroplets and further show that these membrane-free droplets can selectively retain longer length RNAs while permitting transfer of lower molecular weight oligonucleotides.

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 Dates: 2018
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-018-06072-w
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 3643 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723