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  Site‐Specific Deoxyfluorination of Small Peptides with [18F]Fluoride

Rickmeier, J., & Ritter, T. (2018). Site‐Specific Deoxyfluorination of Small Peptides with [18F]Fluoride. Angewandte Chemie International Edition, 57(43), 14207-14211. doi:10.1002/anie.201807983.

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 Creators:
Rickmeier, Jens1, Author              
Ritter, Tobias1, Author              
Affiliations:
1Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              

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Free keywords: deoxyfluorination; η6 activation; fluorine; peptide labeling; radiochemistry
 Abstract: Radiolabeled receptor‐binding peptides are an important class of positron emission tomography tracers owing to achievable high binding affinities and their rapid blood clearance. Herein, a method to introduce a 4‐[18F]fluoro‐phenylalanine residue into peptide sequences is reported, by chemoselective radio‐deoxyfluorination of a tyrosine residue using a traceless activating group. The replacement of only one hydrogen atom with [18F]fluoride results in minimal structural perturbation of the peptide, which is desirable in the labeling of tracer candidates.

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Language(s): eng - English
 Dates: 2018-07-122018-09-062018-10-22
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201807983
 Degree: -

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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie, International Edition
  Other : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 57 (43) Sequence Number: - Start / End Page: 14207 - 14211 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851