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  Palladium-Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature

Pan, F., Boursalian, G. B., & Ritter, T. (2018). Palladium-Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature. Angewandte Chemie International Edition, 57(51), 16871-16876. doi:10.1002/anie.201811139.

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Genre: Journal Article

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 Creators:
Pan, Fei1, Author              
Boursalian, Gregory B.1, Author              
Ritter, Tobias1, Author              
Affiliations:
1Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              

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Free keywords: decarbonylation; difluoromethylation; homogeneous catalysis; palladium;room temperature
 Abstract: Methods for the direct synthesis of difluoromethylated arenes are sparse, despite the importance of the difluoromethyl group in medical, agro‐, and materials chemistry. A palladium‐catalyzed decarbonylative cross‐coupling reaction of acid chlorides with a difluoromethyl zinc reagent is achieved to access difluoromethylated compounds. The transformation proceeds at room temperature and shows broad functional group tolerance, thus providing a general and efficient method for decarbonylative difluoromethylation of a wide range of aromatic carboxylic acids.

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Language(s): eng - English
 Dates: 2018-09-272018-10-242018-12-17
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201811139
 Degree: -

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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie, International Edition
  Other : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 57 (51) Sequence Number: - Start / End Page: 16871 - 16876 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851