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  Highly flexible infection programs in a specialized wheat pathogen

Haueisen, J., Möller, M., Eschenbrenner, C. J., Grandaubert, J., Seybold, H., Adamiak, H., et al. (2019). Highly flexible infection programs in a specialized wheat pathogen. Ecology and Evolution, 9(1), 275-294. doi:10.1002/ece3.4724.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-F79B-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-F79C-8
Genre: Journal Article

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 Creators:
Haueisen, Janine1, Author              
Möller, Mareike1, Author              
Eschenbrenner, Christoph J.1, Author              
Grandaubert, Jonathan1, Author              
Seybold, Heike, Author
Adamiak, Holger, Author
Stukenbrock, Eva H.1, Author              
Affiliations:
1Max Planck Fellow Group Environmental Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2068284              

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Free keywords: onfocal microscopy, expression phenotypes, host specialization, infection phenotypes, plant–fungus interactions, Zymoseptoria tritici
 Abstract: Many filamentous plant pathogens exhibit high levels of genomic variability, yet the impact of this variation on host-pathogen interactions is largely unknown. We have addressed host specialization in the wheat pathogen Zymoseptoria tritici. Our study builds on comparative analyses of infection and gene expression phenotypes of three isolates and reveals the extent to which genomic variation translates into phenotypic variation. The isolates exhibit genetic and genomic variation but are similarly virulent. By combining confocal microscopy, disease monitoring, staining of ROS, and comparative transcriptome analyses, we conducted a detailed comparison of the infection processes of these isolates in a susceptible wheat cultivar. We characterized four core infection stages: establishment, biotrophic growth, lifestyle transition, and necrotrophic growth and asexual reproduction that are shared by the three isolates. However, we demonstrate differentiated temporal and spatial infection development and significant differences in the expression profiles of the three isolates during the infection stages. More than 20% of the genes were differentially expressed and these genes were located significantly closer to transposable elements, suggesting an impact of epigenetic regulation. Further, differentially expressed genes were enriched in effector candidates suggesting that isolate-specific strategies for manipulating host defenses are present in Z. tritici. We demonstrate that individuals of a host-specialized pathogen have highly differentiated infection programs characterized by flexible infection development and functional redundancy. This illustrates how high genetic diversity in pathogen populations results in highly differentiated infection phenotypes, which fact needs to be acknowledged to understand host-pathogen interactions and pathogen evolution.

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Language(s): eng - English
 Dates: 2018-10-042018-08-232018-10-052018-12-262019-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/ece3.4724
 Degree: -

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Title: Ecology and Evolution
Source Genre: Journal
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Affiliations:
Publ. Info: John Wiley & Sons, Inc.
Pages: - Volume / Issue: 9 (1) Sequence Number: - Start / End Page: 275 - 294 Identifier: ISSN: 2045-7758
CoNE: https://pure.mpg.de/cone/journals/resource/2045-7758