English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Funktion und Komplexität in Wirbeltiergenomen

Piontke, J. C. (2018). Funktion und Komplexität in Wirbeltiergenomen. Master Thesis, Universität zu Lübeck, Institut für Neuro- und Bioinformatik, Lübeck.

Item is

Basic

show hide
Genre: Thesis
Other : Function and Complexity in Vertebrate Genomes

Files

show Files
hide Files
:
Piontke_Jessica_master_2018.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
Piontke_Jessica_master_2018.pdf
Description:
-
OA-Status:
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Piontke, Jessica Christin1, Author
Haubold, Bernhard1, Advisor           
Affiliations:
1Research Group Bioinformatics, Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445644              

Content

show
hide
Free keywords: -
 Abstract: In vertebrate genomes, non-repeated sequence regions are associated with genetic
functions. Measuring uniqueness of sequence regions can be done with the match
complexity. The change in match complexity along a genome sequence is determined
by a sliding window analysis. In this way, the complexity for partial sequences of the
genome is obtained. The greater the proportion of unique segments of a partial sequence,
the higher its match complexity. Repeating partial sequences therefore have a low match
complexity, unique sequences a high match complexity.
This thesis examines the relationship between complexity and function in vertebrate
genomes. Here I show that regions with high match complexity in the genomes of frog,
chicken, cow, mouse, human, rat, chimpanzee and zebrafish have up to 38 times more
developmental genes than expected. This extends the previous knowledge on mammalian
genomes in mice and human to a representative group of vertebrates. For small window
sizes of around 10 kilobases, high-complexity regions of mammals contain an aboveaverage
number of genes. In long areas of high complexity, the Ttn gene and genes of the
Hox clusters are found in vertebrates. It could be shown that high-complexity regions
of chicken, mouse, human, rat and zebrafish are enriched with developmental processes.
The observed developmental processes mainly contribute to embryonic development or
the formation of anatomical structures.
The results demonstrate a significant correlation between high complexity of genomic
sequences and developmental functions in vertebrates. They thus broaden our understanding
of the relationship between nucleic acid sequences and biological function.
Complexity measurements can be used as a starting point for functional analysis of
vertebrate genomes. Here, highly complex regions without a known function would be
promising candidates for future experimental studies.

Details

show
hide
Language(s): deu - German
 Dates: 2018-12-202018-12-20
 Publication Status: Issued
 Pages: 53
 Publishing info: Lübeck : Universität zu Lübeck, Institut für Neuro- und Bioinformatik
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: Dipl/13105
 Degree: Master

Event

show

Legal Case

show

Project information

show

Source

show