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  Microenvironment-derived ADAM28 prevents cancer dissemination.

Gerard, C., Hubeau, C., Carnet, O., Bellefroid, M., Sounni, N. E., Blacher, S., et al. (2018). Microenvironment-derived ADAM28 prevents cancer dissemination. Oncotarget, 9(98), 37185-37199. doi:10.18632/oncotarget.26449.

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26449-1016897-7-PB.pdf (Publisher version), 5MB
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 Creators:
Gerard, Catherine1, Author
Hubeau, Celine1, Author
Carnet, Oriane1, Author
Bellefroid, Marine1, Author
Sounni, Nor Eddine1, Author
Blacher, Silvia1, Author
Bendavid, Guillaume1, Author
Moser, Markus2, Author              
Fässler, Reinhard2, Author              
Noel, Agnes1, Author
Cataldo, Didier1, Author
Rocks, Natacha1, Author
Affiliations:
1external, ou_persistent22              
2Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Free keywords: ADAM28; lung; metastasis; CD8+; T lymphocytes
 Abstract: Previous studies have linked cancer cell-associated ADAM28 expression with tumor progression and metastatic dissemination. However, the role of host-derived ADAM28 in cancer dissemination processes remains unclear. Genetically engineered-mice fully deficient for ADAM28 unexpectedly display increased lung colonization by pulmonary, melanoma or breast tumor cells. In experimental tumor cell dissemination models, host ADAM28 deficiency is further associated with a decreased lung infiltration by CD8+ T lymphocytes. Notably, naive ADAM28-deficient mice already display a drastic reduction of CD8+ T cells in spleen which is further observed in lungs. Interestingly, ex vivo CD8+ T cell characterization revealed that ADAM28-deficiency does not impact proliferation, migration nor activation of CD8+ T cells. Our data highlight a functional role of ADAM28 in T cell mobilization and point to an unexpected protective role for host ADAM28 against metastasis.

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 Dates: 2018-122018
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: ISI: 30647853
DOI: 10.18632/oncotarget.26449
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Title: Oncotarget
Source Genre: Journal
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Pages: - Volume / Issue: 9 (98) Sequence Number: - Start / End Page: 37185 - 37199 Identifier: ISSN: 1949-2553
CoNE: https://pure.mpg.de/cone/journals/resource/1949-2553