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  Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication

Scherr, M. J., Safaric, B., & Duderstadt, K. E. (2018). Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication. Bioessays, 40(2): 1700159. doi:10.1002/bies.201700159.

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 Creators:
Scherr, Matthias J.1, Author              
Safaric, Barbara1, Author              
Duderstadt, Karl E.1, Author              
Affiliations:
1Duderstadt, Karl / Structure and Dynamics of Molecular Machines, Max Planck Institute of Biochemistry, Max Planck Society, ou_2265639              

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Free keywords: DNA replication exchange flow stretching Mcm2‐7 single‐molecule
 Abstract: The astonishing efficiency and accuracy of DNA replication has long suggested that refined rules enforce a single highly reproducible sequence of molecular events during the process. This view was solidified by early demonstrations that DNA unwinding and synthesis are coupled within a stable molecular factory, known as the replisome, which consists of conserved components that each play unique and complementary roles. However, recent single‐molecule observations of replisome dynamics have begun to challenge this view, revealing that replication may not be defined by a uniform sequence of events. Instead, multiple exchange pathways, pauses, and DNA loop types appear to dominate replisome function. These observations suggest we must rethink our fundamental assumptions and acknowledge that each replication cycle may involve sampling of alternative, sometimes parallel, pathways. Here, we review our current mechanistic understanding of DNA replication while highlighting findings that exemplify multi‐pathway aspects of replisome function and considering the broader implications.

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 Dates: 2018-01
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000427311600003
DOI: 10.1002/bies.201700159
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Title: Bioessays
  Other : Bioessays
Source Genre: Journal
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Publ. Info: Cambridge, UK : Co. of Biologists
Pages: - Volume / Issue: 40 (2) Sequence Number: 1700159 Start / End Page: - Identifier: ISSN: 0265-9247
CoNE: https://pure.mpg.de/cone/journals/resource/954925499109