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  Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer.

Thakur, C., Rapp, U. R., & Rudel, T. (2018). Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer. Oncotarget, 9(5), 6518-6535. doi:10.18632/oncotarget.23785.

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 Creators:
Thakur, Chitra1, Author           
Rapp, Ulf R.2, Author           
Rudel, Thomas3, Author
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565172              
2Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              
3external, ou_persistent22              

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Free keywords: lung cancer; metastasis; cysts; lineage tracing; dedifferentiation
 Abstract: Identifying metastatic tumor growth at an early stage has been one of the biggest challenges in the treatment of lung cancer. By genetic lineage tracing approach in a conditional model of Non-Small Cell Lung Cancer (NSCLC) in mice, we demonstrate that cystic lesions represent an early stage of metastatic invasion. We generated a mouse model for NSCLC which incorporated a heritable DsRed fluorescent tag driven by the ubiquitous CAG promoter in the alveolar type II cells of the lung. We found early cystic lesions in a secondary organ (liver) that lacked the expression of bona fide lung makers namely Scgb1a1 and surfactant protein C Sftpc and were DsRed positive hence identifying lung as their source of origin. This demonstrates the significant potential of alveolar type II cells in orchestrating the process of metastasis, rendering it as one of the target cell types of the lung of therapeutic importance in human NSCLC.

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 Dates: 2017-082017-122018
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: ISI: 29464089
DOI: 10.18632/oncotarget.23785
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Title: Oncotarget
Source Genre: Journal
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Pages: - Volume / Issue: 9 (5) Sequence Number: - Start / End Page: 6518 - 6535 Identifier: ISSN: 1949-2553
CoNE: https://pure.mpg.de/cone/journals/resource/1949-2553