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  Perseus: A Bioinformatics Platform for Integrative Analysis of Proteomics Data in Cancer Research

Tyanova, S., & Cox, J. (2018). Perseus: A Bioinformatics Platform for Integrative Analysis of Proteomics Data in Cancer Research. In L. von Stechow (Ed.), Cancer Systems Biology (pp. 133-148). New York, NY: Humana Press. doi:10.1007/978-1-4939-7493-1_7.

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Tyanova-Cox2018_Protocol_PerseusABioinformaticsPlatform.pdf (Publisher version), 778KB
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Tyanova-Cox2018_Protocol_PerseusABioinformaticsPlatform.pdf
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© The Author(s) 2018

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 Creators:
Tyanova, Stefka1, Author           
Cox, Jürgen1, Author           
Affiliations:
1Cox, Jürgen / Computational Systems Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_2063284              

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Free keywords: Perseus; Software; Omics data analysis; Translational bioinformatics Cancer proteomics
 Abstract: Mass spectrometry-based proteomics is a continuously growing field marked by technological and methodological improvements. Cancer proteomics is aimed at pursuing goals such as accurate diagnosis, patient stratification, and biomarker discovery, relying on the richness of information of quantitative proteome profiles. Translating these high-dimensional data into biological findings of clinical importance necessitates the use of robust and powerful computational tools and methods. In this chapter, we provide a detailed description of standard analysis steps for a clinical proteomics dataset performed in Perseus, a software for functional analysis of large-scale quantitative omics data.

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 Dates: 2018-012018
 Publication Status: Issued
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Title: Cancer Systems Biology
  Subtitle : Methods and Protocols
Source Genre: Book
 Creator(s):
von Stechow, Louise, Editor
Affiliations:
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Publ. Info: New York, NY : Humana Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 133 - 148 Identifier: ISSN: 1064-3745
ISBN: 978-1-4939-7493-1; 978-1-4939-7492-4

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Title: Methods in Molecular Biology
Source Genre: Series
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Publ. Info: Humana Press
Pages: - Volume / Issue: 1711 Sequence Number: - Start / End Page: - Identifier: ISSN: 1064-3745