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  Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration

Tay, T. L., Sagar, S., Dautzenberg, J., Grün, D., & Prinz, M. (2018). Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration. Acta Neuropathologica Communications, 6, 87. doi:10.1186/s40478-018-0584-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6E2B-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E621-3
Genre: Journal Article

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 Creators:
Tay, Tuan Leng1, Author
Sagar, Sagar2, Author
Dautzenberg, Jana1, Author
Grün, Dominic2, Author              
Prinz, Marco1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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Free keywords: Microglia, Recovery, Neurodegeneration, Single-cell RNA analysis
 Abstract: Microglia are brain immune cells that constantly survey their environment to maintain homeostasis. Enhanced microglial reactivity and proliferation are typical hallmarks of neurodegenerative diseases. Whether specific disease-linked microglial subsets exist during the entire course of neurodegeneration, including the recovery phase, is currently unclear. Taking a single-cell RNA-sequencing approach in a susceptibility gene-free model of nerve injury, we identified a microglial subpopulation that upon acute neurodegeneration shares a conserved gene regulatory profile compared to previously reported chronic and destructive neurodegeneration transgenic mouse models. Our data also revealed rapid shifts in gene regulation that defined microglial subsets at peak and resolution of neurodegeneration. Finally, our discovery of a unique transient microglial subpopulation at the onset of recovery may provide novel targets for modulating microglia-mediated restoration of brain health.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1186/s40478-018-0584-3
 Degree: -

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Title: Acta Neuropathologica Communications
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 6 Sequence Number: - Start / End Page: 87 Identifier: -