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  Role of mechanical morphogenesis in the development and evolution of the neocortex

Heuer, K., & Toro, R. (2019). Role of mechanical morphogenesis in the development and evolution of the neocortex. Physics of Life Reviews. doi:10.1016/j.plrev.2019.01.012.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-FF78-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7F33-6
Genre: Journal Article

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 Creators:
Heuer, Katja1, 2, Author              
Toro, Roberto1, 3, Author
Affiliations:
1Applied and Theoretical Neuroanatomy Group, Institut Pasteur, Paris, France, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
3Center for Research and Interdisciplinarity (CRI), Université Paris Descartes, France, ou_persistent22              

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Free keywords: Neocortical folding; Mechanical morphogenesis; Buckling; Brain development; Brain evolution
 Abstract: During the short period of brain development, nature is able to build the only system we know capable of producing cognition, language, creativity, and consciousness. The neocortex – the outermost layer of the mammalian cerebrum – appears to be the biological substrate of these abilities. Its development requires not only the precise placement and wiring of billions of cells, but also the implementation of mechanisms to ensure a viable cognition despite sometimes dramatic perturbations. Today, this remarkably complex organisation is thought to be genetically encoded, and further refined by activity-dependent processes. We propose that mechanical morphogenesis – the capacity of homogeneously growing elastic tissue to produce complex shapes – can also play an important role. Out of homogeneous growth, mechanical morphogenesis can induce the segregation of the neocortex into mechanical and geometric modules – the neocortical folds. Through the feedback of physical forces on developing tissue, these modules can influence the differentiation and wiring of the neocortex, having a causal role on neocortical development, and providing adaptable and robust units for its evolution.

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Language(s): eng - English
 Dates: 2019-01-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.plrev.2019.01.012
PMID: 30738760
Other: Epub ahead of print
 Degree: -

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Title: Physics of Life Reviews
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1571-0645
CoNE: https://pure.mpg.de/cone/journals/resource/111087580658010