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  Olfactory receptor and circuit evolution promote host specialization

Auer, T. O., Khallaf, M. A., Silbering, A. F., Zappia, G., Ellis, K., Álvarez-Ocaña, R., et al. (2020). Olfactory receptor and circuit evolution promote host specialization. Nature, 579, 402-408. doi:10.1038/s41586-020-2073-7.

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 Creators:
Auer, Thomas O., Author
Khallaf, Mohammed A.1, 2, Author           
Silbering, Ana F., Author
Zappia, Giovanna, Author
Ellis, Kaitlyn, Author
Álvarez-Ocaña, Raquel, Author
Arguello, J. Roman , Author
Hansson, Bill S.3, Author           
Jefferis, Gregory S.X.E., Author
Caron, Sophie, Author
Knaden, Markus4, Author           
Benton, Richard, Author
Affiliations:
1Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society, ou_421894              
2IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society, Jena, DE, ou_421900              
3Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society, ou_421894              
4Research Group Dr. M. Knaden, Insect Behavior, Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society, ou_421913              

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 Abstract: The evolution of animal behaviour is poorly understood. Despite numerous
correlations of behavioural and nervous system divergence, demonstration of the
genetic basis of interspecific behavioural differences remains rare. Here we
develop a novel neurogenetic model, Drosophila sechellia, a close cousin of D.
melanogaster that displays profound behavioural changes linked to its extreme
host fruit specialisation. Through calcium imaging, we identify olfactory pathways
detecting host volatiles. Mutational analysis indicates roles for individual receptors
in long- and short-range attraction. Cross-species allele transfer demonstrates
that differential tuning of one receptor is important for species-specific behaviour.
We identify the molecular determinants of this functional change, and
characterise their behavioural significance and evolutionary origin. Circuit tracing
reveals that receptor adaptations are accompanied by increased sensory pooling
onto interneurons and novel central projection patterns. This work links molecular
and neuronal changes to behavioural divergence and defines a powerful model
for investigating nervous system evolution and speciation.

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 Dates: 2020-01-312020-03-042020
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: Other: HAN323
DOI: 10.1038/s41586-020-2073-7
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 579 Sequence Number: - Start / End Page: 402 - 408 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238