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  Mapping Optogenetically Driven Single-Vessel fMRI with Concurrent Neuronal Calcium Recordings in the Rat Hippocampus

Chen, X.-M., Sobczak, F., Chen, Y., Qian, C., Lu, Z., Ayata, C., et al. (2019). Mapping Optogenetically Driven Single-Vessel fMRI with Concurrent Neuronal Calcium Recordings in the Rat Hippocampus. Neuron, Epub ahead. doi:10.2139/ssrn.3318946.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-054F-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-72D6-A
Genre: Journal Article

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 Creators:
Chen, X-M1, 2, Author              
Sobczak, F1, 2, Author              
Chen, Y1, 2, Author              
Qian, C, Author
Lu, Z, Author
Ayata, C, Author
Logothetis, NK2, 3, Author              
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: The hippocampus plays critical roles in learning and memory, as well as pathological states such as epilepsy and Alzheimer’s disease. To better understand its neural network function, the multi-modality methodology has been implemented in both in vitro and in vivo conditions. However, the large-scale hippocampal vascular hemodynamic responses linked to specific neural activity remains to be elucidated at the single-vessel level through the hippocampus. We merged the fiber optic calcium recording with optogenetically driven single-vessel fMRI to obtain concurrent neuronal calcium signal with blood-oxygen-level-dependent and cerebral-blood-volume (CBV) signal from individual venules and arterioles, respectively, which are aligned in an interleaved pattern to circulate blood through the hippocampus. This multi-modal fMRI platform detects specific spatiotemporal hemodynamic patterns from hippocampal vasculature correlated with physiologically evoked and spreading depression-like calcium events. The calcium event-related single-vessel fMRI hemodynamic modeling reveals significantly reduced neurovascular coupling efficiency upon spreading depression-like events, providing a direct measure of the hippocampal vascular function at varied states in animal models.

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 Dates: 2019-01
 Publication Status: Published online
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 Identifiers: DOI: 10.2139/ssrn.3318946
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: Epub ahead Sequence Number: - Start / End Page: - Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565