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  Phosphoproteomic analysis of signaling pathways in lymphomas.

Häupl, B., Urlaub, H., & Oellerich, T. (2019). Phosphoproteomic analysis of signaling pathways in lymphomas. In R. Küppers (Ed.), Lymphoma (pp. 371-381).

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-0A7C-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-0A7E-6
Genre: Book Chapter

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 Creators:
Häupl, B., Author
Urlaub, H.1, Author              
Oellerich, T., Author
Affiliations:
1Research Group of Bioanalytical Mass Spectrometry, MPI for biophysical chemistry, Max Planck Society, ou_578613              

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Free keywords: Antigen receptors; B-cell lymphomas; Mass spectrometry; Phosphoproteomics; Signaling
 Abstract: Cell fate decisions are controlled by complex signal transduction processes that transmit information via posttranslational protein modifications such as phosphorylation. In lymphoma, as in other cancer types, these signaling networks are often dysregulated and thus contribute to malignant transformation and tumor maintenance. For example, B-cell antigen receptor signals are rewired in certain lymphoma types, such as diffuse large B-cell lymphomas, to promote cell growth and survival of the malignant cell clones. Hence, global elucidation of such intricate signaling networks is important for an improved understanding of the biology of these tumors and the identification of target proteins for therapeutic purposes.We describe here a mass spectrometry-based phosphoproteomic approach for characterization of intracellular signaling events and their dynamics. This integrated phosphoproteomic technology combines phosphopeptide enrichment and fractionation with liquid-chromatography-coupled mass spectrometry for the site-specific mapping and quantification of thousands of phosphorylation events in a given cell type. Such global signaling analyses provide valuable insights into oncogenic signaling networks and can inform drug development efforts.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/978-1-4939-9151-8_19
 Degree: -

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Title: Lymphoma
Source Genre: Book
 Creator(s):
Küppers, R., Editor
Affiliations:
-
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 371 - 381 Identifier: -

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Title: Methods in Molecular Biology
Source Genre: Series
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