English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Convergent evolution as an indicator for selection during acute HIV-1 infection

Bertels, F., Metzner, K. J., & Regoes, R. R. (2019). Convergent evolution as an indicator for selection during acute HIV-1 infection. Retrieved from http://biorxiv.org/content/early/2018/11/20/168260.abstract.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-0D49-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-0D4A-D
Genre: Paper

Files

show Files
hide Files
:
168260.full.pdf (Preprint), 3MB
Name:
168260.full.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show
hide
Description:
bioRxiv

Creators

show
hide
 Creators:
Bertels, Frederic1, Author              
Metzner, Karin J, Author
Regoes, Roland R, Author
Affiliations:
1Research Group Microbial Molecular Evolution, Department Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2497692              

Content

show
hide
Free keywords: -
 Abstract: Convergent evolution describes the process of different populations acquiring similar phenotypes or genotypes. Complex organisms with large genomes only rarely and only under very strong selection converge to the same genotype. In contrast, independent virus populations with very small genomes often acquire identical mutations. Here we test the hypothesis of whether convergence in early HIV-1 infection is common enough to serve as an indicator for selection. To this end, we measure the number of convergent mutations in a well-studied dataset of full-length HIV-1 env genes sampled from HIV-1 infected individuals during early infection. We compare this data to a neutral model and find an excess of convergent mutations. Convergent mutations are not evenly distributed across the env gene, but more likely to occur in gp41, which suggests that convergent mutations provide a selective advantage and hence are positively selected. In contrast, mutations that are only found in an HIV-1 population of a single individual are significantly affected by purifying selection. Our analysis suggests that comparisons between convergent and private mutations with neutral models allow us to identify positive and negative selection in small viral genomes. Our results also show that selection significantly shapes HIV-1 populations even before the onset of the adaptive immune system.

Details

show
hide
Language(s): eng - English
 Dates: 2018-11-202018-11-202019
 Publication Status: Published in print
 Pages: -
 Publishing info: bioRxiv
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source

show