Membrane fluctuations and acidosis regulate cooperative binding of “marker of 
self” CD47 with macrophage checkpoint receptor SIRPα

Steinkühler, Jan; Różycki, Bartosz; Alvey, Cory; Lipowsky, Reinhard; Weikl, Thomas R.; Dimova, Rumiana; Discher, Dennis E.

doi:10.1242/jcs.216770

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Membrane fluctuations and acidosis regulate cooperative binding of “marker of self” CD47 with macrophage checkpoint receptor SIRPα

Steinkühler, J., Różycki, B., Alvey, C., Lipowsky, R., Weikl, T. R., Dimova, R., et al. (2019). Membrane fluctuations and acidosis regulate cooperative binding of “marker of self” CD47 with macrophage checkpoint receptor SIRPα. Journal of Cell Science, 132: JCS216770. doi:10.1242/jcs.216770.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-18B3-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-5576-9

Genre: Journal Article

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Creators:
Steinkühler, Jan¹, Author
Różycki, Bartosz, Author
Alvey, Cory, Author
Lipowsky, Reinhard², Author
Weikl, Thomas R.³, Author
Dimova, Rumiana¹, Author
Discher, Dennis E., Author

Affiliations:
1Rumiana Dimova, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863328
2Reinhard Lipowsky, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863327
3Thomas Weikl, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863330

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Abstract: Cell-cell interactions that result from membrane proteins binding weakly in trans can cause accumulations in cis that suggest cooperativity and thereby an acute sensitivity to environmental factors. The ubiquitous “marker of self” protein CD47 binds weakly to SIRPα on a macrophage, which leads to accumulation of SIRPα at a phagocytic synapse and ultimately to inhibition of engulfment of ‘self’ cells

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Language(s): eng - English

Dates: Published Online: 2019

Publication Status: Published online

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Identifiers: DOI: 10.1242/jcs.216770

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Title: Journal of Cell Science

Source Genre: Journal

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Publ. Info: Cambridge, U.K. : The Company of Biologists Ltd

Pages: - Volume / Issue: 132 Sequence Number: JCS216770 Start / End Page: - Identifier: ISSN: 0021-9533