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  The plastidial metabolite 2‐C‐methyl‐D‐erythritol‐2,4‐cyclodiphosphate modulates defence responses against aphids

Onkokesung, N., Reichelt, M., Wright, L., Phillips, M. A., Gershenzon, J., & Dicke, M. (2019). The plastidial metabolite 2‐C‐methyl‐D‐erythritol‐2,4‐cyclodiphosphate modulates defence responses against aphids. Plant, Cell and Environment, 42(7), 2309-2323. doi:10.1111/pce.13538.

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http://dx.doi.org/10.1111/pce.13538 (Publisher version)
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 Creators:
Onkokesung, Nawaporn, Author
Reichelt, Michael1, Author              
Wright, Louwrance1, Author              
Phillips, Michael A., Author
Gershenzon, Jonathan1, Author              
Dicke, Marcel, Author
Affiliations:
1Department of Biochemistry, Prof. J. Gershenzon, MPI for Chemical Ecology, Max Planck Society, ou_421893              

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 Abstract: Feeding by insect herbivores such as caterpillars and aphids induces plant resistance mechanisms that are mediated by the phytohormones jasmonic acid (JA) and salicylic acid (SA). These phytohormonal pathways often crosstalk. Besides phytohormones, methyl-D-erythriol-2,4-cyclodiphosphate (MEcPP), the penultimate metabolite in the methyl-D-erythritol-4-phosphate (MEP) pathway, has been speculated to regulate transcription of nuclear genes in response to biotic stressors such as aphids. Here, we show that MEcPP uniquely enhances the SA pathway without attenuating the JA pathway. Arabidopsis mutant plants that accumulate high levels of MEcPP (hds3) are highly resistant to the cabbage aphid (Brevicoryne brassicae) while resistance to the large cabbage white caterpillar (Pieris brassicae) remains unaltered. Thus, MEcPP is a distinct signaling molecule that acts beyond phytohormonal crosstalk to induce resistance against the cabbage aphid in Arabidopsis. We dissect the molecular mechanisms of MEcPP mediating plant resistance against the aphid B. brassicae. This shows that MEcPP induces the expression of genes encoding enzymes involved in the biosynthesis of several primary and secondary metabolic pathways contributing to enhanced resistance against this aphid species. A unique ability to regulate multifaceted molecular mechanisms makes MEcPP an attractive target for metabolic engineering in Brassica crop plants to increase resistance to cabbage aphids.

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 Dates: 2019-02-172019-02-202019-07
 Publication Status: Published in print
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 Identifiers: Other: GER541
DOI: 10.1111/pce.13538
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Title: Plant, Cell and Environment
  Other : Plant, Cell & Environment
Source Genre: Journal
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Publ. Info: Oxford, England : Blackwell Science
Pages: - Volume / Issue: 42 (7) Sequence Number: - Start / End Page: 2309 - 2323 Identifier: ISSN: 0140-7791
CoNE: https://pure.mpg.de/cone/journals/resource/954925471334