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  Real-time MRI for the dynamic assessment of fundoplication failure in patients with gastroesophageal reflux disease.

Seif, A., Hosseini, A., Uhlig, J., Streit, U., Voit, D., Uhlig, A., et al. (2019). Real-time MRI for the dynamic assessment of fundoplication failure in patients with gastroesophageal reflux disease. European Radiology, 29(9), 4691-4698. doi:10.1007/s00330-019-06025-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-1537-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-6DA1-C
Genre: Journal Article

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 Creators:
Seif, A., Author
Hosseini, A., Author
Uhlig, J., Author
Streit, U., Author
Voit, D.1, Author              
Uhlig, A., Author
Ellenrieder, V., Author
Ghadimi, M., Author
Sprenger, T., Author
Beham, A., Author
Uecker, M., Author
Frahm, J.1, Author              
Lotz, J., Author
Biggemann, L., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: Fundoplication; Gastroesophageal reflux disease (GERD); Magnetic resonance imaging
 Abstract: To assess the diagnostic potential of dynamic real-time MRI for fundoplication failure in patients with persistent or recurrent GERD-like (gastroesophageal reflux disease) complaints. MATERIAL AND METHODS: Twenty-two consecutive patients (male n = 11; female n = 11; median age 59 years) with recurrent or persistent GERD-like symptom after fundoplication were enrolled between 2015 and 2017. Median duration of GERD-like symptoms was 21 months. Real-time MRI (3 Tesla) was performed at 40 ms temporal resolution using undersampled radial fast low-angle shot acquisitions with nonlinear inverse image reconstruction. MRI movies dynamically visualized bolus transit of pineapple juice through the gastroesophageal junction, position of the fundoplication wrap and recurring hernia or reflux during Valsalva maneuver. MRI results were compared to endoscopic findings. RESULTS: Real-time MRI was successfully completed in all patients without adverse events (average examination time 15 min). Morphological correlates for GERD-like symptoms were evident in 20 patients (90.1%) with gastric reflux in 19 cases. Nine patients (40.1%) had wrap disruption and recurrent gastric hernia. Wrap migration or telescoping hernia was detected in nine patients (40.1%). One patient presented with continued reflux despite intact fundoplication wrap. Esophageal dysmotility with delayed bolus passage was observed in one case. On endoscopy, gastric hernia or wrap disruption was diagnosed in seven cases, and esophagitis or Barret's metaplasia in nine cases. CONCLUSION: Real-time MRI is a fast and safe modality for dynamic imaging after fundoplication, without radiation exposure or administration of gadolinium-based contrast media. In a relevant number of cases, real-time MRI reveals correlates for GERD-like symptoms. KEY POINTS: • Real-time MRI reliably visualizes the gastroesophageal junction after fundoplication surgery. • Patients with recurring GERD-like symptoms have a high rate of morphological failure patterns that can be identified by real-time MRI. • Dynamic assessment of gastroesophageal junction by real-time MRI is a perspective diagnostic tool for detection of fundoplication failure.

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Language(s): eng - English
 Dates: 2019-02-252019-09
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00330-019-06025-x
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Title: European Radiology
Source Genre: Journal
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Pages: - Volume / Issue: 29 (9) Sequence Number: - Start / End Page: 4691 - 4698 Identifier: -