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  Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology

Vasylyeva, T. I., du Plessis, L., Pineda-Peña, A. C., Kühnert, D., Lemey, P., Vandamme, A.-M., et al. (2019). Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology. The Journal of Infectious Diseases, 220(2), 233-243. doi:10.1093/infdis/jiz085.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-191A-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-D2A5-5
Genre: Journal Article

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 Creators:
Vasylyeva, Tetyana I., Author
du Plessis, Louis, Author
Pineda-Peña, Andrea C., Author
Kühnert, Denise1, Author              
Lemey, Philippe, Author
Vandamme, Anne-Mieke, Author
Gomes, Perpétua, Author
Camacho, Ricardo J., Author
Pybus, Oliver G., Author
Abecasis, Ana B., Author
Faria, Nuno R., Author
Affiliations:
1tide, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2591691              

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 Abstract: Estimation of temporal changes in HIV transmission patterns can help to elucidate the impact of preventative strategies and public health policies. Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference datasets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific effective reproductive numbers (Re). Discrete trait analysis (DTA) was used to quantify mixing among transmission groups. We identified five subtype B Portuguese clades (n=26-79 sequences) and a large monophyletic subtype G Portuguese clade (n=236). We estimated that major shifts in HIV-1 transmission occurred around 1999 (95\% Bayesian credible interval 1998-2000) and 2000 (1998-2001) for subtypes B and G, respectively. For subtype B, Re dropped from 1.91 (1.73-2.09) to 0.62 (0.52-0.72). For subtype G, Re decreased from 1.49 (1.39-1.59) to 0.72 (0.63-0.8). The DTA suggests that people who inject drugs (PWID) and heterosexuals were at the source of most (>80\%) virus lineage transitions for subtypes G and B, respectively. The estimated declines in Re coincide with the introduction of highly active antiretroviral therapy and the scale-up of harm reduction for PWID. Inferred transmission events across transmission groups emphasize the importance of prevention efforts for bridging populations.

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Language(s): eng - English
 Dates: 2019-02-262019-07-15
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1093/infdis/jiz085
Other: shh1186
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Title: The Journal of Infectious Diseases
Source Genre: Journal
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Publ. Info: Chicago, Ill. : Published by the University of Chicago Press for the Infectious Diseases Society of America
Pages: - Volume / Issue: 220 (2) Sequence Number: - Start / End Page: 233 - 243 Identifier: ISSN: 0022-1899
CoNE: https://pure.mpg.de/cone/journals/resource/954925414917_1