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  Diffusion-weighted MRI of the prostate without susceptibility artifacts: Undersampled multi-shot turbo-STEAM with rotated radial trajectories.

Merrem, A., Hofer, S., Seif Amir Hosseini, A., Voit, D., Merboldt, K. D., Tan, Z., et al. (2019). Diffusion-weighted MRI of the prostate without susceptibility artifacts: Undersampled multi-shot turbo-STEAM with rotated radial trajectories. NMR in Biomedicine, 32(5): e4074. doi:10.1002/nbm.4074.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-1C85-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7683-4
Genre: Journal Article

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 Creators:
Merrem, A.1, Author              
Hofer, S.1, Author              
Seif Amir Hosseini, A., Author
Voit, D.1, Author              
Merboldt, K. D.1, Author              
Tan, Z.1, Author              
Frahm, J.1, Author              
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: Cancer; diffusion-weighted MRI; iterative reconstruction; prostate; radial sampling
 Abstract: The aim of this study was to develop and evaluate a clinically feasible approach to diffusion-weighted (DW) MRI of the prostate without susceptibility-induced artifacts. The proposed method relies on an undersampled multi-shot DW turbo-STEAM sequence with rotated radial trajectories and a multi-step inverse reconstruction with denoised multi-shot phase maps. The total acquisition time was below 6 min for a resolution of 1.4 × 1.4 × 3.5 mm3 and six directions at b = 600 s mm-2 . Studies of eight healthy subjects and two patients with prostate cancer were performed at 3 T employing an 18-channel body-array coil and elements of the spine coil. The method was compared with conventional DW echo-planar imaging (EPI) of the prostate. The results confirm that DW STEAM MRI avoids geometric distortions and false image intensities, which were present for both single-shot EPI (ssEPI) and readout-segmented EPI, particularly near the intestinal wall of the prostate. Quantitative accuracy of the apparent diffusion coefficient (ADC) was validated with use of a numerical phantom providing ground truth. ADC values in the central prostate gland of healthy subjects were consistent with those measured using ssEPI and with literature data. Preliminary results for patients with prostate cancer revealed a correct anatomical localization of lesions with respect to T2 -weighted MRI in both mean DW STEAM images and ADC maps. In summary, DW STEAM MRI of the prostate offers clinically relevant advantages for the diagnosis of prostate cancer compared with state-of-the-art EPI-based approaches. The method warrants extended clinical trials.

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Language(s): eng - English
 Dates: 2019-03-052019-05
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/nbm.4074
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Title: NMR in Biomedicine
Source Genre: Journal
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Pages: 9 Volume / Issue: 32 (5) Sequence Number: e4074 Start / End Page: - Identifier: -