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  Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe

Mohamed, A. M. M., Retzke, T., Das Chakraborty, S., Fabian, B., Hansson, B. S., Knaden, M., et al. (2019). Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe. Nature Communications, 10: 1201. doi:10.1038/s41467-019-09069-1.

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http://dx.doi.org/10.1038/s41467-019-09069-1 (Publisher version)
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 Creators:
Mohamed, Ahmed M. M.1, 2, Author              
Retzke, Tom1, 2, Author              
Das Chakraborty, Sudeshna1, Author              
Fabian, Benjamin2, 3, Author              
Hansson, Bill S.1, Author              
Knaden, Markus4, Author              
Sachse, Silke1, Author              
Affiliations:
1Department of Evolutionary Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society, ou_421894              
2IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society, Jena, DE, ou_421900              
3Research Group Dr. S. Sachse, Olfactory Coding, MPI for Chemical Ecology, Max Planck Society, ou_421914              
4Research Group Dr. M. Knaden, Insect Behavior, Department of Neuroethology, Prof. B. S. Hansson, MPI for Chemical Ecology, Max Planck Society, ou_421913              

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 Abstract: Evaluating odor blends in sensory processing is a crucial step for signal recognition and execution of behavioral decisions. Using behavioral assays and 2-photon imaging, we have characterized the neural and behavioral correlates of mixture perception in the olfactory system of Drosophila. Mixtures of odors with opposing valences elicit strong inhibition in certain attractant-responsive input channels. This inhibition correlates with reduced behavioral attraction. We demonstrate that defined subsets of GABAergic interneurons provide the neuronal substrate of this computation at pre- and postsynaptic loci via GABAB- and GABAA receptors, respectively. Intriguingly, manipulation of single input channels by silencing and optogenetic activation unveils a glomerulus-specific crosstalk between the attractant- and repellent-responsive circuits. This inhibitory interaction biases the behavioral output. Such a form of selective lateral inhibition represents a crucial neuronal mechanism in the processing of conflicting sensory information.

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 Dates: 20192019-03-13
 Publication Status: Published online
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 Identifiers: Other: SAC015
DOI: 10.1038/s41467-019-09069-1
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 10 Sequence Number: 1201 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723